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ProteomicsPhosphoproteomic analysis of WT and KO JNK1 mice
In this study we compared the phopshoproteome of brain from wild type and Jnk1 knockout mice over life time.
ORGANISM(S): Mus musculus (Mouse) 
2024-05-23 | PXD016530 | Pride
Phosphoproteomics Brain Shotgun 
ProteomicsJNK-regulated phosphoproteome links synaptic and metabolic pathways to mood regulation
JNKs play critical roles in neuronal damage associated with neurodegenerative disease and inhibitors of JNK1 have shown anxiolytic and anti-depressive effects in mice. In this study, we analyze the phosphoproteomes of hippocampus and nucleus accumbens in mice treated with DJNKI-1, a JNK inhibitor.
ORGANISM(S): Mus musculus (Mouse) 
2025-12-02 | PXD060057 | Pride
ProteomicsRegulators of proteostasis are translationally repressed in fibroblasts from sporadic and LRRK2-G2019S Parkinson’s patients
Here we used non-canonical amino acid labeling and mass-spectrometry based proteomics to perform a quantitative comparison of nascent proteins in fibroblasts from sporadic and G2019S mutation PD patients compared to healthy individuals. We found that several proteins were under-represented among ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-21 | PXD031144 | Pride
Parkinson's disease Protein synthesis 
TranscriptomicsATF3 is a positive regulator of human IFN gene expression
The aim of this study was to identify genes regulated by IL-12, IL-18 and IFN-alpha during early differentiation of human Th1 cells Human cord blood CD4+ T cells were activated via TCR and cultured in the presence of IL-12, IFN-alpha or IL-12+IL-18. Cytokine induced gene expression was compared to a...
ORGANISM(S): Homo sapiens 
2010-04-11 | E-GEOD-20198 | biostudies-arrayexpress
GenomicsDAC_for_study___T2D_RV_pilot_NTR
Data Access Committee EGAC00001000029
EGAC00001000029 | EGA
GenomicsEGAS00001000134-sc-20110901 - samples
Description not provided
EGAD00001000037 | EGA
GenomicsAn evaluation of different strategies for large scale pooled sequencing study design
Second generation sequencing technology has enabled the design of large-scale sequencing experiments in targeted disease-related regions in thousands of cases and controls. Cost implications dictate a pooled DNA sequencing design, evaluation of allele frequency differences based on the resequenced s...
EGAS00001000134 | EGA
GenomicsGencode Exome Pilot
Data Access Committee EGAC00001000001
EGAC00001000001 | EGA
GenomicsEGAS00001000016-sc-20110221 - samples
Gencode Exome Pilot
EGAD00001000003 | EGA
GenomicsThe GENCODE exome sequencing the complete human exome
We report the design of an extended set of targets for capturing the complete human exome, based on annotation from the GENCODE consortium. The extended set covers an addition 5,594 genes and 10.3 Mb compared to current sets which mainly target the CCDS database. The additional regions include poten...
EGAS00001000016 | EGA
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