Sort   by:  
 Page size 

Patterns in functional diversity of organisms at large spatial scales can provide insight into possible responses to future climate change, but it remains a challenge to link large-scale patterns at the organismal level to their underlying physiological mechanisms. The climate variability hypothe...

2022-01-20 | MTBLS3627 | MetaboLights
Background and Objectives Molecular omics studies have identified proteins related to cognitive resilience but unrelated to Alzheimer disease and Alzheimer disease–related dementia (AD/ADRD) pathologies. Posttranslational modifications of proteins with glycans can modify protein function. In this s...
ORGANISM(S): Homo sapiens (Human) 
2025-12-24 | PXD072371 | Pride
We implemented an integrative systems-level analysis of multi-region postmortem human brain proteomics derived from the Religious Order and Rush Memory and Aging Project (ROSMAP) to identify proteins and pathways significantly altered in resilient cases. ROSMAP is an information-rich longitudinal co...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD040224 | Pride
Identifying main functional pathways associated with cognitive resilience to Alzheimer ´s Disease
Cyclic GMP-AMP synthase and interferon activation diminish MEF2C-mediated cognitive resilience IV
Cyclic GMP-AMP synthase and interferon activation diminish MEF2C-mediated cognitive resilience II
ZCCHC17 modulates neuronal RNA splicing and supports cognitive resilience in Alzheimer’s disease
An aging-sensitive compensatory neuroprotective factor that confers cognitive resilience
Pharmacological inhibition of cGAS with TDI-6570 protected against the synaptic loss and cognitive deficits in P301S tauopathy model, likely via enhancing MEF2C transcriptional network and associated cognitive resilience
ORGANISM(S): Mus musculus 
2023-04-26 | GSE226383 | GEO
Understanding the mechanisms involved in cognitive resilience in Alzheimer’s disease (AD) represents a promising strategy to identify novel treatments for dementia in AD. Previous findings from our group revealed that the study of aged-Tg2576 cognitive resilient individuals is a suitable tool for th...
ORGANISM(S): Mus musculus 
2023-09-19 | GSE180968 | GEO
Sort   by:  
 Page size