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ProteomicsUSP8 maintains ESC stemness via deubiquitination of EPG5
The coiled-coil domain of EPG5 was synthesized as follows: Biotin-MNKNEAVSQQIHVLQKEVRQLQAE AAQ (from Beijing SciLight Biotechnology, LCC). 1 mg of this short peptide was incubated with ES cells lysates followed by immunoprecipitation with anti-biotin beads. The precipitates were extensively washed w...
ORGANISM(S): Mus musculus (Mouse) 
2019-02-25 | PXD012563 | Pride
I.e.mouse.escs.epg5.usp8.lc-msms 
GenomicsInhibition of Rho-associated, coiled-coil-containing protein kinase 2 in murine podocytes
Inhibition of Rho-associated, coiled-coil-containing protein kinase 2 in murine podocytes
PRJNA1090039 | ENA
GenomicsFolding of cohesin's coiled coil is important for Scc2/4-induced association with chromosomes
Folding of cohesin's coiled coil is important for Scc2/4-induced association with chromosomes
PRJNA704282 | ENA
ProteomicsCryo-EM structures of the Plant Augmin reveal its intertwined coiled-coil assembly, antiparallel dimerization and NEDD1 binding mechanisms
Microtubule (MT) branch nucleation is fundamental for building parallel MT networks in eukaryotic cells. In plants and metazoans, MT branch nucleation requires Augmin and NEDD1 proteins which bind along MTs and then recruit and activate the gamma-tubulin ring complex (g-TuRC). Augmin is a fork-shap...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2025-10-31 | PXD065516 | Pride
Microtubule Augmin G-turc Xl-ms Nedd1 
ProteomicsCoiled-Coil Domain-Containing 68 Downregulation Promotes Colorectal Cancer Cell Growth by Inhibiting ITCH-Mediated CDK4 Degradation
Coiled-coil domain-containing 68 (CCDC68) plays different roles in cancer and is predicted as a tumor suppressor in human colorectal cancer (CRC). However, the specific role of CCDC68 in CRC and the underlying mechanisms remain unknown. Here, we showed that CCDC68 expression was lower in CRC than in...
ORGANISM(S): Homo sapiens (Human) 
2021-04-14 | PXD024343 | Pride
Ccdc68 Itch Cdk4 degradation Cell proliferation Colorectal cancer 
GenomicsA 36-base hairpin within lncRNA DRAIC interacts with the IKKα coiled-coil domain, weakening the IKK complex and inhibiting NF-kappaB activation
A 36-base hairpin within lncRNA DRAIC interacts with the IKKα coiled-coil domain, weakening the IKK complex and inhibiting NF-kappaB activation
PRJNA1171344 | ENA
OtherA 36-base hairpin within lncRNA DRAIC interacts with the IKKα coiled-coil domain, weakening the IKK complex and inhibiting NF-kappaB activation
Long noncoding RNAs have diverse functions, but not enough is known about the molecular mechanisms underlying their cellular functions. The 1.7 kb long down-regulated non-coding RNA in cancers (DRAIC) slows tumor growth and inhibits the activation of the transcription factor NF-kappaB through intera...
ORGANISM(S): Homo sapiens 
2025-07-01 | GSE279192 | GEO
UnknownMolecular basis of coiled-coil formation.
Not available
S-EPMC1855353 | biostudies-literature
GenomicsEffects of depletion of Rho-associated, coiled-coil-containing protein kinase 2 in the kidney medullary tussue of murine model.
Effects of depletion of Rho-associated, coiled-coil-containing protein kinase 2 in the kidney medullary tussue of murine model.
PRJNA1031226 | ENA
UnknownA seven-helix coiled coil.
Not available
S-EPMC1622844 | biostudies-literature
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