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TranscriptomicsGenome-wide mRNA expression profiling for Wild Type and Itch-/- Skin Transcriptomes by RNA sequencing
To test the hypothesis that defects in the termination of inflammatory signaling led to skin inflammation that results in the “Itchy” phenotype, we isolated RNA from the lesional skin of Itch-/- mice and from the skin of wild-type mice and performed genome-wide mRNA expression profiling by RNA seque...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-65686 | biostudies-arrayexpress
TranscriptomicsRNA-seq of splenic B cells derived from WT and Itch cKO mice
We found that the E3 ubiquitin ligase Itch significantly affects early B-cell differentiation. To explore the role of Itch in late B-cell differentiation, we sorted B cells from WT and Itch cKO mice. To explore the effect of Itch deficency on gene expression, we determined mRNA profiles in B cells ...
ORGANISM(S): Mus musculus 
2020-03-01 | E-MTAB-8281 | biostudies-arrayexpress
TranscriptomicsRNA-seq of splenic B cells derived from WT and Itch KO mice
We found that the E3 ubiquitin ligase Itch significantly affects early B-cell differentiation. To explore the role of Itch in late B-cell differentiation, we sorted B cells from WT and Itch KO mice. To explore the effect of Itch deficency on gene expression, we determined mRNA profiles in B cells f...
ORGANISM(S): Mus musculus 
2020-03-01 | E-MTAB-8273 | biostudies-arrayexpress
ProteomicsItch Ubiquitin Ligase Deficiency and B cell LC-MSMS
The E3 ubiquitin ligase Itch regulates antibody levels and prevents autoimmune disease in humans and mice, yet how Itch regulates B cell fate or function is unknown. We now show that Itch directly limits B cell activity. Using LC-MSMS, we profiled and compared the whole cell proteomes of Itch defici...
ORGANISM(S): Mus musculus (Mouse) 
2019-07-12 | PXD014243 | Pride
Itch ubiquitin ligase Lc-msms Tlr9 B cell 
ProteomicsRole of ITCH in the endolysosomal damage response
Ubiquitin remnant (diGly) profiling of parental and ITCH knockout (KO) cells under endolysosomal damage conditions (LLOMe).
ORGANISM(S): Homo sapiens (Human) 
2024-10-18 | PXD039088 | Pride
Digly Itch Lysosome Llome Ubiquitin 
ProteomicsHuman LC-MS (ITCH-Mediated Golgi Fragmentation Drives Proteotoxicity in Neurodegeneration)
To identify host proteins that interact with ITCH, we performed proteomic analysis of the co-immunoprecipitates pulled down by the ITCH expressed in HEK293 cells.
ORGANISM(S): Homo sapiens (Human) 
2025-09-19 | PXD057324 | Pride
Neurodegeneration 
ProteomicsItch attenuates CD4 T cell proliferation in mice by limiting WBP2 protein stability
To mount an anti-pathogen response, CD4 T cells must undergo rapid cell proliferation. However, poorly controlled expansion can result in diseases such as autoimmunity. One important regulator of T cell activity is the E3 ubiquitin ligase Itch. Itch deficient patients suffer from extensive autoinfla...
ORGANISM(S): Mus musculus (Mouse) 
2021-01-07 | PXD019272 | Pride
Proliferation E3 ubiquitin ligase Cell cycle Autoinflammation 
UnknownA neuropeptide code for itch.
Not available
S-EPMC9437842 | biostudies-literature
UnknownConopeptides promote itch through human itch receptor hMgprX1.
Not available
S-EPMC6299835 | biostudies-literature
UnknownTRP Channels as Drug Targets to Relieve Itch.
Not available
S-EPMC6316386 | biostudies-literature
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