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MetabolomicsShotgun lipidomics of HeLa whole-cell lysates and lysosomes following LLOMe treatment

Perturbations in lysosome integrity are tightly linked to neurological disorders and ageing, but the underlying pathogenic mechanisms are incompletely understood. Using an unbiased proteomic approach, we here identified the bridge-like lipid transport protein VPS13C/PARK23 as a key component of a...

2026-07-03 | MTBLS14737 | MetaboLights
ProteomicsSILAC APEX2-GAL9 upon LLOMe or GPN treatment
Proximity proteomics of GAL9 upon lysosomal damage by LLOMe or GPN. Proximity labeling was performed in SILAC labelled HEK293T cells stably expressing APEX2-GAL9.
ORGANISM(S): Homo sapiens (Human) 
2020-01-30 | PXD015779 | Pride
Gal9 Apex2 Llome Gpn Lysosomes 
GenomicsRNA Sequencing of LLOMe treated MEF cells
RNA Sequencing of LLOMe treated MEF cells
PRJEB82901 | ENA
GenomicsRNA-Seq of MEF cells treated with LLOMe
RNA-Seq of MEF cells treated with LLOMe
PRJEB90175 | ENA
GenomicsATAC sequencing of untreated and LLOMe treated MEF cells
ATAC sequencing of untreated and LLOMe treated MEF cells
PRJEB83051 | ENA
TranscriptomicsRNA Sequencing of LLOMe treated MEF cells
To understand the transcriptomic changes upon LLOMe treatment at different time points.
ORGANISM(S): Mus musculus 
2025-07-04 | E-MTAB-14641 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of MEF cells treated with LLOMe
To understand the transcriptomic changes upon LLOMe treatment at different time points.
ORGANISM(S): Mus musculus 
2025-07-04 | E-MTAB-15207 | biostudies-arrayexpress
TranscriptomicsATAC sequencing of untreated and LLOMe treated MEF cells
Analyzing chromatin accessibility in MEF cells pre treatment and post treatment of LLOMe at different time points. (30mins, 3hrs and 30hrs).
ORGANISM(S): Mus musculus 
2025-07-04 | E-MTAB-14658 | biostudies-arrayexpress
ProteomicsRole of ITCH in the endolysosomal damage response
Ubiquitin remnant (diGly) profiling of parental and ITCH knockout (KO) cells under endolysosomal damage conditions (LLOMe).
ORGANISM(S): Homo sapiens (Human) 
2024-10-18 | PXD039088 | Pride
Digly Itch Lysosome Llome Ubiquitin 
ProteomicsLysosomal damage proteomics in HeLa cells
To identify ubiquitylation targets following lysosomal damage in HeLa cells treated with LLOMe we performed quantitative ubiquitin-remmnant (diGly) profilig coupled to mass spectrometry (MS). In addition, we performed APEX2-based proximity biotinylation followed by MS analysis to identify proximity ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD029926 | Pride
Apex2 Lysosome Proxiity biotinylation Llome Digly proteomics Ubiquitin Cnn2 
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