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ProteomicsVCP-dependent CNN2 proximity proteomics
Lysosomal membrane permeabilization (LMP) is an underlying feature of diverse conditions including neurodegeneration. Cells respond by extensive ubiquitylation of membrane-associated proteins for clearance of the organelle through lysophagy that is facilitated by the ubiquitin-directed AAA-ATPase VC...
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD032903 | Pride
Cnn2 Apex2 Nms873 Vcp 
UnknownCNN2 silencing inhibits colorectal cancer development through promoting ubiquitination of EGR1.
Not available
S-EPMC10185810 | biostudies-literature
ProteomicsLysosomal damage proteomics in HeLa cells
To identify ubiquitylation targets following lysosomal damage in HeLa cells treated with LLOMe we performed quantitative ubiquitin-remmnant (diGly) profilig coupled to mass spectrometry (MS). In addition, we performed APEX2-based proximity biotinylation followed by MS analysis to identify proximity ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD029926 | Pride
Apex2 Lysosome Proxiity biotinylation Llome Digly proteomics Ubiquitin Cnn2 
TranscriptomicsCalponin 2 regulates ketogenesis to dictate the outcome of acute kidney injury
Calponin 2 (CNN2) is a prominent actin stabilizer. It regulates fatty acid oxidation (FAO) by interacting with estrogen receptor 2 (ESR2) to determine kidney fibrosis. However, whether CNN2 is actively involved in acute kidney injury (AKI) remains unclear. Here, we report that CNN2 was induced in hu...
ORGANISM(S): Mus musculus 
2023-10-02 | GSE226534 | GEO
ProteomicsThe functions and pathways related to CNN2 in LUAD cells
To determine the effects of CNN2 knockdown on the molecular phenotype of NSCLC cells, global RNA-Seq-based transcriptomic analysis was performed in parallel with global tandem mass tag multiplexing-based proteomic analysis in A549 cells transduced with shCtrl or shCNN2 . Knockdown of CNN2 resulted i...
ORGANISM(S): Homo Sapiens 
PXD066183 |
TranscriptomicsGene expression profiling of shCtrl and shCNN2 RKO cells from Clariom S array.
CNN2 is identified as a tumor promotor in the development of colorectal cancer. Herein, gene expression in RKO cells infected with shCtrl and shCNN2 (for CNN2 knockdown) was detected with a Clariom S array. Gene expression profiling of shCtrl and shCNN2 RKO cells was acquired and analyzed. Different...
ORGANISM(S): Homo sapiens 
2023-05-04 | GSE229716 | GEO
UnknownThe Role of H2-Calponin Antigen in Cancer Metastasis: Presence of Autoantibodies in Liver Cancer Patients.
Not available
S-EPMC10298237 | biostudies-literature
UnknownCalponin 2 regulates ketogenesis to mitigate acute kidney injury.
Not available
S-EPMC10721266 | biostudies-literature
UnknownArtificial intelligence for diagnosing neoplasia on digital cholangioscopy: development and multicenter validation of a convolutional neural network model.
Not available
S-EPMC10374349 | biostudies-literature
UnknownCalponin 2 harnesses metabolic reprogramming to determine kidney fibrosis.
Not available
S-EPMC10090436 | biostudies-literature
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