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ProteomicsVCP–adaptor interactions are exceptionally dynamic and subject to differential modulation by a VCP inhibitor
In this study we use a combination of mass spectrometry-based proteomics and biophysical studies to characterize the interaction of adaptors with VCP. Our results reveal that most VCP–adaptor interactions are characterized by exceptionally rapid dynamics that in some cases are modulated by the VCP i...
ORGANISM(S): Homo sapiens (Human) 
2016-07-18 | PXD004105 | Pride
Ap-ms Sec-ms Vcp/p97 Protein complex dynamics Crosslinking-ms Orbitrap 
UnknownValosin-containing protein (VCP)-Adaptor Interactions are Exceptionally Dynamic and Subject to Differential Modulation by a VCP Inhibitor.
Not available
S-EPMC5013311 | biostudies-literature
ProteomicsVCP-dependent CNN2 proximity proteomics
Lysosomal membrane permeabilization (LMP) is an underlying feature of diverse conditions including neurodegeneration. Cells respond by extensive ubiquitylation of membrane-associated proteins for clearance of the organelle through lysophagy that is facilitated by the ubiquitin-directed AAA-ATPase VC...
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD032903 | Pride
Cnn2 Apex2 Nms873 Vcp 
ProteomicsImmunoprecipitation of p97 from X.laevis S-phase chromatin
Complex cellular processes are driven by the regulated assembly and disassembly of large multi-protein complexes. In eukaryotic DNA replication, whilst we are beginning to understand the molecular mechanism for assembly of the replication machinery (replisome), we still know little about the regulat...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2022-10-14 | PXD029705 | Pride
Vcp Replisome disassembly Xenopus laevis P97 Dna replication 
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