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TranscriptomicsCell intrinsic expression of TLR9 in autoreactive B cells constrains BCR/TLR7-dependent responses
Endosomal Toll-like receptors (TLRs) play an important role in the etiology of systemic autoimmune diseases such as SLE, where DNA- and RNA-associated autoantigens activate autoreactive B cells through TLR9- and TLR7-dependent pathways, respectively. Nevertheless, TLR9-deficient autoimmune prone mic...
ORGANISM(S): Mus musculus 
2015-03-04 | E-GEOD-58756 | biostudies-arrayexpress
ProteomicsTLR9-Driven S-Palmitoylation in Dendritic Cells Reveals Immune and Metabolic Protein Targets
Dendritic cells (DCs) rely on Toll-like receptor 9 (TLR9) to detect unmethylated CpG motifs in microbial DNA, triggering essential immune responses. While the downstream signaling pathways of TLR9 activation are well characterized, their impact on S-palmitoylation is unknown. S-palmitoylation, invol...
ORGANISM(S): Mus musculus (Mouse) 
2025-08-25 | PXD066223 | Pride
Tlr9 Dendritic cells. S-palmitoylation 
TranscriptomicsShort and long-term changes in gene expression mediated by the activation of TLR9
CpG DNA binds to Toll-like receptor 9 to stimulate a strong innate immune response. Despite extensive studies of TLR9 mediated signal transduction, the scope of CpG-induced changes in gene expression is incompletely understood. In particular, the prolonged effects of CpG ODN (oligodeoxynucleotide) o...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-16465 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse AM-14 B cells stimulated through the B cell receptor (BCR) and/or Toll-like receptors (TLR)
We have previously shown that rheumatoid factors (RF) produced by Fas-deficient autoimmune-prone mice typically bind autologous IgG2a with remarkably low affinity. Nevertheless, B cells representative of this RF population proliferate vigorously in response IgG2a/chromatin immune complexes through a...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6674 | biostudies-arrayexpress
TranscriptomicsCharacterization of the regulatory networks mediating TLR9 dependent gene activation in vivo
CpG DNA interacts with TLR9 to stimulate a broadly protective innate immune response. This study uses bioinformatic network analysis of microarray data to identify the genes and regulatory networks triggered by CpG ODN. CpG treatment induced significant gene up-regulation (p < 0.00001) in the spleen...
ORGANISM(S): Mus musculus 
2009-04-01 | E-GEOD-11202 | biostudies-arrayexpress
TranscriptomicsTLR9 deficiency promotes CD73 expression in T cells and diabetes protection in NOD mice
Analyze the effect of TLR9 deficiency on immue cell function at the gene expression level. Our hypothesis was that TLR9 deficiency promotes CD73 expression in T cells thus regulates autoimmune diabetes development in NOD mice. Sorted TCRb+ cells were pooled from several mice for furhter RNA extracti...
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-48781 | biostudies-arrayexpress
TranscriptomicsToll-like receptor 2 (TLR2)-TLR9 crosstalk dictates IL-12 family cytokine production in microglia
Microglia are the resident mononuclear phagocytes of the CNS parenchyma and represent an initial line of defense against invading microorganisms. Microglia utilize Toll-like receptors (TLRs) for pathogen recognition and TLR2 specifically senses conserved motifs of gram-positive bacteria including li...
ORGANISM(S): Mus musculus 
2014-12-22 | E-GEOD-24935 | biostudies-arrayexpress
TranscriptomicsSca-1 expression defines different developmental stages of mouse PDC that show functional heterogeneity in the endosomal but not lysosomal TLR9 response
Plasmacytoid dendritic cells (PDC) play an important role in innate and adaptive immunity and were shown to be identical to previously described natural IFN-M-NM-1-producing cells (NIP). Here, we describe two functionally distinct PDC subpopulations that are characterized by the differential express...
ORGANISM(S): Mus musculus 
2013-12-21 | E-GEOD-42860 | biostudies-arrayexpress
GenomicsEffect of CXCL4 on TLR9-induced B cells
Effect of CXCL4 on TLR9-induced B cells
PRJNA946137 | ENA
GenomicsFormation of Memory Assemblies through the DNA Sensing Tlr9 Pathway
Formation of Memory Assemblies through the DNA Sensing Tlr9 Pathway
PRJNA1071681 | ENA
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