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ProteomicsCol4a3 mouse glomerular datasets
Glomeruli were isolated from Col4a3-/- and Ctrl mice. The extracellular matrix was enriched and both cellular and matrix fraction were analysed by mass spectrometry.
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD022392 | Pride
Kidney Glomerulus Mouse Col4a3 Extracellular matrix 
GenomicsTauroursodeoxycholic acid ameliorates renal injury induced by COL4A3 mutation
Tauroursodeoxycholic acid ameliorates renal injury induced by COL4A3 mutation
PRJNA1087890 | ENA
GenomicsAlport (Col4a3-/-) Mouse Recapitulates Heart Failure with Preserved Ejection Fraction Pathologies Driven by Osteopontin-Mitochondria Axis
Alport (Col4a3-/-) Mouse Recapitulates Heart Failure with Preserved Ejection Fraction Pathologies Driven by Osteopontin-Mitochondria Axis
PRJNA497812 | ENA
TranscriptomicsAlport (Col4a3-/-) Mouse Recapitulates Heart Failure with Preserved Ejection Fraction Pathologies Driven by Osteopontin-Mitochondria Axis
Hearts were snap frozen from 2 month old wild type, Col4a3-/-, or Col4a3-/-OPN-/- mice. RNA was isolated using Mirvana Paris kit.
ORGANISM(S): Mus musculus 
2018-10-23 | GSE121576 | GEO
UnknownPolymorphisms in COL4A3 and COL4A4 genes associated with keratoconus.
Not available
S-EPMC2796875 | biostudies-literature
TranscriptomicsmRNA profiling of Col4a3-Knockout Alport Syndrome mouse model treated with inhibitor of miR-21 at 5.5 weeks of age
Purpose: MicroRNA-21 contributes to the pathogenesis of fibrogenic diseases in multiple organs including the kidney. To evaluate the therapeutic utility of antimiR-21 oligonucleotides in chronic kidney disease, we silenced miR-21 in mice that develop Alport Nephropathy due to a defect in the Col4a3 ...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-62294 | biostudies-arrayexpress
UnknownThe Phenotypic Spectrum of COL4A3 Heterozygotes.
Not available
S-EPMC10168410 | biostudies-literature
UnknownPresumed COL4A3/COL4A4 Missense/Synonymous Variants Induce Aberrant Splicing.
Not available
S-EPMC8977549 | biostudies-literature
TranscriptomicsTauroursodeoxycholic acid ameliorates renal injury induced by COL4A3 mutation
COL4A3/A4/A5 mutations have been identified as critical causes of Alport syndrome and other genetic chronic kidney diseases. However, the underlying pathogenesis remains unclear, and specific treatments are lacking. Here, we constructed a transgenic Alport syndrome mouse model by generating a mutati...
ORGANISM(S): Mus musculus 
2024-08-28 | GSE261588 | GEO
TranscriptomicsmRNA profiling of Col4a3-Knockout Alport Syndrome mouse model treated with inhibitor of miR-21 at 9 weeks of age
Purpose: MicroRNA-21 contributes to the pathogenesis of fibrogenic diseases in multiple organs including the kidney. To evaluate the therapeutic utility of antimiR-21 oligonucleotides in chronic kidney disease, we silenced miR-21 in mice that develop Alport Nephropathy due to a defect in the Col4a3 ...
ORGANISM(S): Mus musculus 
2015-01-01 | E-GEOD-62292 | biostudies-arrayexpress
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