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UnknownAppetite Suppression and Altered Food Preferences Coincide with Changes in Appetite-Mediating Hormones During Energy Deficit at High Altitude, But Are Not Affected by Protein Intake.
Not available
S-EPMC6014054 | biostudies-literature
MetabolomicsNQO1 protects obese mice through improvements in glucose and lipid metabolism.
Chronic nutrient excess leads to metabolic disorders and insulin resistance. Activation of stress-responsive pathways via Nrf2 activation contributes to energy metabolism regulation. Here, inducible activation of Nrf2 in mice and transgenesis of the Nrf2 target, NQO1, conferred protection from diet-...
2024-05-23 | MTBLS2085 | MetaboLights
MetabolomicsOn-line targeted metabolomics for real-time monitoring of relevant compounds in fermentation processes
Fermentation monitoring is a powerful tool for bioprocess development and optimisation. On-line metabolomics is a technology that is starting to gain attention as a bioprocess monitoring tool, allowing the direct measurement of many compounds in the fermentation broth at a very high time resolution....
2024-03-05 | MTBLS7889 | MetaboLights
TranscriptomicsMolecular signatures of peripheral blood mononuclear cells following chronic IFN-alpha: Relationship of OAS2 with Depression and Fatigue
Interferon (IFN)-alpha causes high rates of depression and fatigue, and is used to investigate the impact of innate immune cytokines on brain and behavior. However, little is known about transcriptional profiles of circulating immune cells during chronic IFN-alpha administration. Accordingly, genome...
ORGANISM(S): Homo sapiens 
2012-01-01 | E-GEOD-31187 | biostudies-arrayexpress
ProteomicsTLR9-activated B cells imprint adoptively transferred CD8+ T cells with potent tumor immunity and persistence
Here we report a new way to reverse the tolerant state of adoptively transferred CD8+ T cells against melanoma through ex vivo expansion with the TLR9 agonist CpG. CpG-generated T cells elicited potent immunity without co-administration of high dose IL-2 or vaccination, which are adjuvants classical...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD022909 | Pride
T cells adoptive cell transfer therapy toll-like receptors melanoma b cells 
MetabolomicsOn-line untargeted metabolomics monitoring of an Escherichia coli succinate fermentation process
The real-time monitoring of metabolites (RTMet) is instrumental for the industrial production of biobased fermentation products. This study shows the first application of untargeted on-line metabolomics for the monitoring of undiluted fermentation broth samples taken automatically from a 5 L bioreac...
2023-04-26 | MTBLS5197 | MetaboLights
ProteomicsStress-induced interactome of the O-GlcNAcase by SILAC-BioID-MS/MS
O-linked-β-N-acetylglucosamine (O-GlcNAc) dynamically modifies and regulates thousands of nuclear, cytoplasmic, and mitochondrial proteins. Cellular stress, including oxidative stress, results in increased O-GlcNAcylation on numerous proteins and this is thought to promote cell survival. The mechani...
ORGANISM(S): Homo sapiens (Human) 
2017-03-14 | PXD005039 | Pride
Glycosylation Mgea5 Fasn Silac O-glcnac Human Bioid 
UnknownActivated mTOR Signaling in the RPE Drives EMT, Autophagy, and Metabolic Disruption, Resulting in AMD-Like Pathology in Mice.
Not available
S-EPMC12151893 | biostudies-literature
UnknownA randomized trial comparing the efficacy and safety of intravitreal triamcinolone with standard care to treat vision loss associated with macular Edema secondary to branch retinal vein occlusion: the Standard Care vs Corticosteroid for Retinal Vein Occlusion (SCORE) study report 6.
Not available
S-EPMC2806600 | biostudies-literature
UnknownFactors Associated With Revision Surgery After Internal Fixation of Hip Fractures.
Not available
S-EPMC5986292 | biostudies-literature
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