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TranscriptomicsFunctionally-relevant splicing of resident pre-mRNAs in anucleate platelets upon activation by physiological stimuli
Platelet activation is the key event triggering thrombus formation in physiological and pathological conditions, such as acute coronary syndromes. Current therapies using antiaggregants still fail to prevent thrombotic coronary events in a significant number of patients, indicating that the mechanis...
ORGANISM(S): Homo sapiens 
2018-01-15 | E-MTAB-6148 | biostudies-arrayexpress
TranscriptomicsDehydration impaired normal renal development in infant mice
The kidney is a major organ in which fluid balance and waste excretion is regulated. To obtain mature functions of the kidney, normal renal developmental processes need to be preceded. Comprehensive genetic programs underlying renal development during prenatal life have been widely studied. However,...
ORGANISM(S): Mus musculus 
2016-07-01 | E-GEOD-75604 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of esg+-midgut progenitor cells expressing esgRNAi or UAS-esg AND of whole midgut tissue from flies overexpressing UAS-esg in enterocyte (EC) cells
RNA-Seq of amplified mRNA from sorted esg+-midgut progenitor cells expressing esgRNAi or UAS-esg AND RNA-Seq of whole midgut tissue from flies overexpressing UAS-esg and UAS-esg+UAS-dIAP (+control empty vector RNAi, UAS-dIAP and w1118) using the MyoIA-Gal4ts EC-driver
ORGANISM(S): Drosophila melanogaster 
2014-10-25 | E-MTAB-2915 | biostudies-arrayexpress
TranscriptomicsExpression Profile of Skeletal Muscle from Young and Aged C57B1/6 Mice
Our laboratory wanted to define the transcription profile of aged skeletal muscle. For this reason, we performed a triplicate microarray study on young (3 weeks) and aged (24 months) gatrocnemius muscle from wild-type C57B16 Mice Keywords: other this experiment include 2 samples and 6 replicates
ORGANISM(S): Mus musculus 
2009-02-26 | E-GEOD-14678 | biostudies-arrayexpress
ProteomicsSynthesis of flavonol-bearing probes and chemical proteomic analysis of Asteraceae petals in search of flavonoid enzymes
In flowers of Asteraceae, yellow flavonols bearing an additional hydroxyl group at positions 6 or 8 (ring A) contribute to petal UV-absorbing pigmentation patterns, which play a crucial role in attracting pollinating insects. Understanding the biogenesis of these special flavonols requires the ident...
ORGANISM(S): Rudbeckia hirta Tagetes erecta 
2023-07-20 | PXD041520 | Pride
Natural products • plant polyphenols • proteomics • bioinformatics • biosynthesis of higher hydroxylated flavonols 
TranscriptomicsMigrating Schistosoma japonicum schistosomula induce type-2 inflammation in the murine lung
Migrating schistosomula are an important stage of the schistosome lifecycle and represent a key target for elimination of infection by natural and vaccine induced host immune responses. To gain a better understanding of how these parasites initiate a primary host immune response we have characterise...
ORGANISM(S): Mus musculus 
2011-02-10 | E-GEOD-27171 | biostudies-arrayexpress
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