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MetabolomicsMitochondrial NAD+ Deficiency in Vascular Smooth Muscle Impairs Collagen III Turnover to Trigger Aortic Disease

Aortic disease poses a significant mortality risk in adults, yet many of its underlying factors remain undiscovered. In this study, we identify mitochondrial NAD⁺ deficiency as a causal factor. Metabolomics analysis of 73 surgical aortic specimens revealed impaired NAD⁺ salvage and mitochondrial ...

2024-12-04 | MTBLS8062 | MetaboLights
MetabolomicsCollagen induced arthritis in dba/1j mice associates with oxylipin changes in plasma
Oxylipins play important roles in various biological processes and are considered as mediators of inflammation for a wide range of diseases such as rheumatoid arthritis (RA). The purpose of this research was to study differences in oxylipin levels between a widely used collagen-induced arthritis (CI...
2015-11-04 | MTBLS243 | MetaboLights
ProteomicsMass spectrometric analysis of Collagen alpha-1 (II) chain from Capra hircus
Expressional alterations and post translational modifications (PTM) of type II collagen can be major cause behind osteo and rheumatoid arthritis. PTM of type II collagen α1 chain (COL2A1) such as hydroxylation of proline (P), lysine and glycosylation of hydroxylysine can act as epitopes resulting CO...
ORGANISM(S): Capra hircus (Goat) 
2019-05-06 | PXD012911 | Pride
Capra hircus Collagen alpha-i (ii) Post translational modifications Hydroxyproline mapping 
ProteomicsMass spectrometric analysis of Collagen alpha-1 (II) chain from Capra hircus
Expressional alterations and post translational modifications (PTM) of type II collagen can be major cause behind osteo and rheumatoid arthritis. PTM of type II collagen α1 chain (COL2A1) such as hydroxylation of proline (P), lysine and glycosylation of hydroxylysine can act as epitopes resulting CO...
ORGANISM(S): Capra hircus (Goat) 
2019-05-06 | PXD012928 | Pride
Capra hircus Collagen alpha-i (ii) Post translational modifications Hydroxyproline mapping 
ProteomicsAdministration of recombinant HSP47 as a new therapeutic approach to stimulate collagen secretion and ameliorate ECM in osteogenesis imperfecta
Collagen misfolding, reduced collagen secretion and incorporation into the extracellular matrix, and impaired collagen organization are common features both in a physiological condition like aging and in pathological conditions like genetic diseases caused by defects in collagen or collagen related ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD047320 | Pride
Proteomics  nanolc-ms/ms 
ProteomicsMeta-proteomic analysis of two mammoth’s trunk for an indirect picture of their habitat and characterization of the alpha-1 type I collagen sequence
The investigation of archaeological samples, which are of inestimable value, requires minimally destructive or non-destructive sampling techniques. One of the most promising and recent non-invasive techniques is known under the acronym EVA, an ethylene vinyl acetate film which avoids contamination a...
ORGANISM(S): Mammuthus primigenius 
2022-05-19 | PXD029558 | Pride
Meta-proteomics Paleoproteomic Mammoth High-resolution mass spectrometry Non-invasive technique Collagen 
TranscriptomicsCollagen Dynamics and Transcriptional Profiling in Bleomycin-induced Pulmonary Fibrosis
Collagen deposition is a key process during idiopathic pulmonary fibrosis (IPF); however, little is known about the dynamics of collagen formation during disease development. Tissue samples of early stages of human disease are not readily available and it is difficult to identify changes in collagen...
ORGANISM(S): Mus musculus 
2013-05-26 | E-GEOD-37635 | biostudies-arrayexpress
TranscriptomicsRNA-seq of cancer cell collagen tracks
Collagen tracks deposited by breast cancer cells contain specific miRNAs which reprogram non-invasive cells into highly pro-metastatic ones by inducing a partial epithelial–mesenchymal transition (EMT) associated with an increase in ECM degradation and cell invasiveness.
ORGANISM(S): Homo sapiens 
2025-12-14 | E-MTAB-15636 | biostudies-arrayexpress
TranscriptomicsCathepsin K Contributes to Cavitation and Collagen Turnover in Pulmonary Tuberculosis
Cavitation in tuberculosis (TB) enables highly efficient person-to-person aerosol transmission. Currently, a number of hypotheses exist regarding the mechanisms underlying this process. To explore this process, we undertook an unbiased next-generation transcriptional analysis of samples from cavity ...
ORGANISM(S): Oryctolagus cuniculus 
2015-11-03 | E-GEOD-68206 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of gene expression changes in human alveolar epithelial cells grown on collagen- or matrigel-coated dishes
Analysis of human alveolar epithelial cell signatures at gene expression level. The aim of the study was to identify candidate genes that are induced in human alveolar epithelial type II cells on collagen-coated dishes. Results provide important information about changes hAT2 cells undergo in the tr...
ORGANISM(S): Homo sapiens 
2014-02-01 | E-GEOD-40516 | biostudies-arrayexpress
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