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ProteomicsOptimizing Small and Large Brain-Derived Extracellular Vesicle Purification Reveals Critical Pathways in Alzheimer's Disease Patients
At this day, Alzheimer’s disease is the most prominent form of dementia worldwide. It is characterized by tau lesions that spread throughout the brain in a spatio-temporal manner. This has led to the prion-like propagation hypothesis implicating a transfer of pathological tau seeds from cell-to-cell...
ORGANISM(S): Homo sapiens (Human) 
2025-12-15 | PXD055734 | Pride
Clu Collagenase brain dissociation Fermt2 Extracellular vesicles Gwas Proteomic profiling Alzheimer's disease 
TranscriptomicsRNA-seq of microglia and monocyte-derived cells in Nrf2 knockout and wild-type mice after induced intracerebral hemorrhage or sham treatment
Secondary injury causes death and dependence after spontaneous intracerebral haemorrhage (ICH). Having found that ICH is associated with activation of genes regulated by the transcription factor Nrf2, particularly in mononuclear myeloid cells (for example, monocyte-derived cells (MdC) and microglia)...
ORGANISM(S): Mus musculus 
2024-08-13 | E-MTAB-14324 | biostudies-arrayexpress
ProteomicsEfficient enzyme-free isolation of brain-derived extracellular vesicles
Extracellular vesicles (EVs) have gained significant attention as potential diagnostic and therapeutic tools due to their role in intercellular communication and their ability to encapsulate various biomolecules. However, the isolation of EVs from tissue remains challenging, often requiring enzymati...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2024-11-07 | PXD045737 | Pride
Collagenase-free protocol Prion protein Brain-derived evs Bdevs 
TranscriptomicsRNA-seq of ex vivo primate cells
We isolated monkey brain cells, cultured and sequencing the generated neurospheres using 10X Genomics.
ORGANISM(S): Macaca fascicularis 
2022-03-30 | E-MTAB-10236 | biostudies-arrayexpress
GenomicsSingle-cell RNA sequencing analysis of mouse normal brain and GBM tumors
Single-cell RNA sequencing analysis of mouse normal brain and GBM tumors
PRJNA819475 | ENA
TranscriptomicsMicrovascular endothelial heterogeneity
The goal of this study was to gain insight into the molecular heterogeneity of capillary endothelial cells derived from different organs by microarray profiling of freshly isolated cells and identify transcription factors that may determine the specific gene expression profile of endothelial cells f...
ORGANISM(S): Mus musculus 
2015-02-19 | E-GEOD-48209 | biostudies-arrayexpress
TranscriptomicsAn in vivo neuroimmune organoid model to study human brain environment-dependent microglia phenotypes
Characterization of human stem cell-derived microglia (hMG) that develop within vascularized human brain organoids under physiological conditions in vivo. We isolated tdT+/CD45+ hMG from five animals and three time points (6, 12 and 24 weeks post transplantation) using Fluorescence-activated cell so...
ORGANISM(S): Homo sapiens 
2023-05-11 | E-MTAB-11522 | biostudies-arrayexpress
GenomicsMutant FGFR3 restricts bone yet expands brain via ERK-mediated self-repression
Mutant FGFR3 restricts bone yet expands brain via ERK-mediated self-repression
PRJNA1401577 | ENA
UnknownStratification of brain-derived extracellular vesicles of Alzheimer's disease patients indicates a unique proteomic content and a higher seeding capacity of small extracellular vesicles.
Not available
S-EPMC12679798 | biostudies-literature
TranscriptomicsSingle-cell RNA-sequencing of multi-organ metastasis in the VO-PyMT mouse model of breast cancer
Metastasis frequently affects multiple organs in  stage IV breast cancer patients and is associated with dismal outcomes. The mechanisms enabling cancer cell colonization across diverse anatomical sites remain poorly understood, mainly due to lack of models of systemic disease and of studies in clin...
ORGANISM(S): Mus musculus 
2026-07-31 | E-MTAB-16621 | biostudies-arrayexpress
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