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MetabolomicsDe Novo Pyrimidine Synthesis Is a Collateral Metabolic Vulnerability in NF2-deficient Mesothelioma

Pleural mesothelioma (PM) is one of the deadliest cancers, with limited therapeutic options due to its therapeutically intractable genome, which is characterized by the functional inactivation of tumor suppressor genes (TSGs) and high tumor heterogeneity, including diverse metabolic adaptations. ...

2025-07-07 | MTBLS12461 | MetaboLights
TranscriptomicsTranscription profiling of human coronary arteries from patients with and without collateral artery vessels to identify novel markers of coronary collateralization
Evaluation of transcriptional regulation in Coronary artery disease patients with and without collateral artery vessels.
ORGANISM(S): Homo sapiens 
2006-03-10 | E-MEXP-564 | biostudies-arrayexpress
TranscriptomicsSuppression of ischemia in arterial occlusive disease by JNK-promoted native collateral artery development
Arterial occlusive diseases are major causes of morbidity and mortality. Blood flow to the affected tissue must be restored quickly if viability and function are to be preserved. Collaterals are artery-to-artery or arteriole-to-arteriole interconnections that can bypass an occlusion by providing an ...
ORGANISM(S): Mus musculus 
2016-08-09 | E-GEOD-71159 | biostudies-arrayexpress
TranscriptomicsRole of redox-dependent, flow-related regulation of AT1R expression in collateral growth impairment
Genomic analysis of control and collateral arteries was used to investigate mechanisms responsible for impaired collateral growth in the Spontaneously Hypertensive rat, an animal model of essential hypertension with increased oxidative and nitrosative stress and metabolic abnormalities. A fundament...
ORGANISM(S): Rattus norvegicus 
2010-12-15 | E-GEOD-19524 | biostudies-arrayexpress
GenomicsNegative autoregulation mitigates collateral RNase activity of repeat-targeting CRISPR-Cas13d in mammalian cells
Negative autoregulation mitigates collateral RNase activity of repeat-targeting CRISPR-Cas13d in mammalian cells
PRJNA790986 | ENA
ProteomicsProteomic analysis reveals the high specificity and lack of collateral activity of targeted PspCas13b
To gain a global view on the impact of the collateral activity on protein expression levels, mass spectrometry was used for proteomics analysis of HEK 293T cells when PspCas13b was co-expressed with non-targeted (NT) crRNA or targeting (T) crRNA, which targets the BCR-ABL1 mRNA breakpoint. There was...
ORGANISM(S): Homo sapiens (Human) 
2024-05-20 | PXD051089 | Pride
Hek293 t cells Pspcas13b Collateral activity 
Genomicstranscriptome-wide collateral effects of Cas13d variants
transcriptome-wide collateral effects of Cas13d variants
PRJNA1081889 | ENA
TranscriptomicsNegative autoregulation mitigates collateral RNase activity of repeat-targeting CRISPR-Cas13d in mammalian cells
Cas13 is a unique family of CRISPR endonucleases exhibiting programmable binding and cleavage of RNAs and is a strong candidate for eukaryotic RNA knockdown in the laboratory and the clinic. However, sequence-specific binding of Cas13 to the target RNA unleashes non-specific bystander RNA cleavage, ...
ORGANISM(S): Homo sapiens 
2021-12-23 | GSE191329 | GEO
TranscriptomicsCharacterizing the Collateral Activity of CRISPR/Cas13 in Mammalian Cells: Implications for RNA Editing and Therapeutic Applications
The CRISPR/Cas13 system has garnered attention as a potential tool for RNA editing. However, the degree of collateral activity among various Cas13 orthologs and their cytotoxic effects in mammalian cells remain contentious, potentially impacting their applications. In this study, we observed differe...
ORGANISM(S): Homo sapiens 
2024-01-25 | GSE254168 | GEO
TranscriptomicsTranscription profiling of human monocytes from individuals with different collateral flow index CFI obtained during angioplasty
using peripheral blood monocytes to identify marker genes for an extensively grown coronary collateral circulation. We used microarrays to detail the global programme of gene expression underlying collateralization and identified distinct classes of differently regulated genes during this process....
ORGANISM(S): Homo sapiens 
2008-10-26 | E-GEOD-7638 | biostudies-arrayexpress
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