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TranscriptomicsExploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution
In this study, using a murine model of Ph+ acute lymphoblastic leukemia (Ph+ ALL), a combined pharmacological profile and drug selection experimental approach identified distinct stages of tumor clonal evolution with vulnerabilities to sets of small molecules. Through genotypic, phenotypic, signalin...
ORGANISM(S): Mus musculus 
2016-04-05 | E-GEOD-72910 | biostudies-arrayexpress
ProteomicsEvolutionary collateral sensitivity to pleuromutilins in vancomycin-resistant Enterococcus faecium
The rise of antibiotic resistance and decline of antibiotic discovery urgently calls for novel mechanistic understanding of pharmacological and evolutionary interactions between antibiotics and multidrug resistant bacteria to revitalize existing antibiotics. The evolutionary cross-resistance to anti...
ORGANISM(S): Enterococcus faecalis (Streptococcus faecalis) 
2022-05-20 | PXD030906 | Pride
Collateral sensitivity，vancomycin-resistant enterococcus faecium，pleuromutilin 
GenomicsMutational Basis of Ceftazidime-Borrelidin A Collateral Sensitivity in Escherichia coli
Genomics of Collateral Sensitivity
PRJEB94349 | ENA
GenomicsPhenotypic convergent evolution towards fosfomycin collateral sensitivity of Pseudomonas aeruginosa antibiotic resistant mutants
Phenotypic convergent evolution towards fosfomycin collateral sensitivity of Pseudomonas aeruginosa antibiotic resistant mutants
PRJNA641152 | ENA
GenomicsCollateral Sensitivity Pseudomonas
Phenotypic convergence in response to drug exposure supports exploitation of collateral sensitivity to counter drug resistance
PRJEB22929 | ENA
GenomicsExploiting collateral sensitivity in the evolution of resistance to tyrosine kinase inhibitors in soft tissue sarcomas.
Exploiting collateral sensitivity in the evolution of resistance to tyrosine kinase inhibitors in soft tissue sarcomas.
PRJNA1268584 | ENA
Proteomicssuppression of PPARGC1A causes collateral sensitivity to HMGCR-inhibitor within BRAFi-treatement resistant melanoma
We aimed to identify the potential proteins as a collateral vulnerability within PGC1a-suppressed BRAF-inhibitor resistant melanomas, and the potential mechanisms behind this including their abundancy and cellular distribution.
ORGANISM(S): Homo sapiens (Human) 
2023-06-09 | PXD041952 | Pride
Melanoma statin ppargc1a statin 
Genomics
Collateral sensitivity-driven therapies against tigecycline-resistant pathogens
PRJNA1252076 | ENA
TranscriptomicsCollateral sensitivity of antibiotic resistant bacteria to antimicrobial peptides
Cationic antimicrobial peptides (CAPs) are promising novel alternatives to conventional antibacterial agents, but the overlap in resistance mechanisms between small-molecule antibiotics and CAPs is unknown. Does evolution of antibiotic resistance decrease (cross-resistance) or increase (collateral s...
ORGANISM(S): Escherichia coli 
2018-03-29 | GSE96706 | GEO
UnknownThe population genetics of collateral resistance and sensitivity.
Not available
S-EPMC8765753 | biostudies-literature
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