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TranscriptomicsThe placental gene PEG10 promotes progression of neuroendocrine prostate cancer [aCGH]
Neuroendocrine prostate cancer (NEPC) is proliferative, invasive, and untreatable. Its molecular pathogenesis remains poorly understood but appears to require TP53 and RB1 aberration. In this study we modeled the development of NEPC from conventional prostatic adenocarcinoma using a unique patient-d...
ORGANISM(S): Homo sapiens 
2015-01-05 | E-GEOD-59985 | biostudies-arrayexpress
TranscriptomicsThe placental gene PEG10 promotes progression of neuroendocrine prostate cancer [Expression]
Neuroendocrine prostate cancer (NEPC) is proliferative, invasive, and untreatable. Its molecular pathogenesis remains poorly understood but appears to require TP53 and RB1 aberration. In this study we modeled the development of NEPC from conventional prostatic adenocarcinoma using a unique patient-d...
ORGANISM(S): Homo sapiens 
2015-01-05 | E-GEOD-59984 | biostudies-arrayexpress
TranscriptomicsProfiling by array of human Glioblastoma multiforme (GBM) tumor samples to asses the intra-tumoral heterogeneity in genomic copy number aberrations
Glioblastoma multiforme (GBM) is a highly heterogeneous disease that shows an wide range of genetic abnormalities in comparison to other astrocytic tumors. We have extracted between 4 and 8 tumor subsamples from different areas of the malignant tissue that were at least 1cm apart. Our aim to asses t...
ORGANISM(S): Homo sapiens 
2013-02-15 | E-MTAB-1215 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel
Array comparative genomic hybridization characterization and comparison of cell lines from 9 different cancer tissue of origin types (Breast, Central Nervous System, Colon, Leukemia, Melanoma, Non-Small Cell Lung, Ovarian, Prostate, Renal) from NCI-60 panel.
ORGANISM(S): Homo sapiens 
2005-11-23 | E-TABM-65 | biostudies-arrayexpress
TranscriptomicsREST knockdown in LNCaP prostate cancer cells
LNCaP cells were transfected with 3 different REST siRNAs Transcriptomics analysis was performed to compare gene expression changes induced by REST knockdown Genome-wide transcriptomic analysis of LNCaP cells transfected with REST siRNA
ORGANISM(S): Homo sapiens 
2013-10-22 | E-GEOD-51461 | biostudies-arrayexpress
TranscriptomicsLong-term androgen withdrawal and treatment (R1881) of LNCaP-FGC prostate cancer cells
LNCaP cells were cultures in steroid depleted medium for 5 days before treatment with synthetic androgen (R1881, 10nM) for 16h. Transcriptomics analysis was performed to compare gene expression changes induced by androgen withdrawal or androgen treatment. Genome-wide transcriptomic analysis of LNCaP...
ORGANISM(S): Homo sapiens 
2013-10-22 | E-GEOD-51460 | biostudies-arrayexpress
GenomicsOrigins and functional consequence of somatic mitochondrial DNA mutations
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mitochondrial DNA (mtDNA) are unclear. Here, we analysed soma...
EGAS00001000968 | EGA
UnknownIntravenous Vitamin C for Patients Hospitalized With COVID-19: Two Harmonized Randomized Clinical Trials.
Not available
S-EPMC10600726 | biostudies-literature
TranscriptomicsGATA2 as a potential prostate cancer metastasis-driving gene
Metastatic prostate cancer (PCa) is a terminal disease and establishment of novel therapeutic strategy specifically targeting metastasis is critically required for its management. This study was aimed at identifying metastasis-driving genes which could potentially be therapeutic targets for metastat...
ORGANISM(S): Homo sapiens 
2014-01-20 | E-GEOD-49342 | biostudies-arrayexpress
ProteomicsThe proteome of localized prostate cancer, part 2
Proteome characterization of gland confined prostate tumors and non-malignant prostate tissue. Whole cell protein extracts were purified from FFPE radical prostatectomy specimens for a total of 28 tumor samples and 8 adjacent non-malignant prostate tissues. Associated ProteomeXchange identifiers: PX...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2016-08-18 | MSV000080066 | MassIVE
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