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ProteomicsAP-SWATH analysis reveals a direct involvement of VCP/p97 in integrated stress response signalling through CReP/PPP1R15B degradation
The ubiquitin-directed AAA-ATPase VCP/p97 facilitates degradation of misfolded proteins in diverse cellular stress response pathways. Resolving the complexity of dynamic interactions with hosts of accessory proteins and substrates has therefore been a major challenge. Here, we used affinity-purifica...
ORGANISM(S): Homo sapiens (Human) 
2018-04-04 | PXD007876 | Pride
Integrated stress response Ap-swath P97 
UnknownDNA profiling with the 20K apple SNP array reveals Malus domestica hybridization and admixture in M. sieversii, M. orientalis, and M. sylvestris genebank accessions.
Not available
S-EPMC9606829 | biostudies-literature
UnknownMycobacterium avium subsp. paratuberculosis and M. avium subsp. avium are independently evolved pathogenic clones of a much broader group of M. avium organisms.
Not available
S-EPMC2293204 | biostudies-literature
TranscriptomicsA growth-essential Tetrahymena Piwi protein carries tRNA fragment cargo
Argonaute/Piwi proteins associate with small RNAs that typically provide sequence specificity for RNP function in gene and genome regulation. Here we show that Twi12, a Tetrahymena Piwi protein essential for growth, is loaded with mature tRNA fragments. The tightly bound ~18-22 nt tRNA 3M-bM-^@M-^Y ...
ORGANISM(S): Tetrahymena thermophila 
2010-10-26 | E-GEOD-24916 | biostudies-arrayexpress
UnknownDevelopment of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13.
Not available
S-EPMC5509550 | biostudies-literature
UnknownPOLR1B and neural crest cell anomalies in Treacher Collins syndrome type 4.
Not available
S-EPMC7056642 | biostudies-literature
ProteomicsIn vivo and in vitro proteome analysis of HIV-1 infected, human CD4+ T cells
Host directed therapies against HIV-1 are thought to be critical for long term containment of the HIV-1 pandemic but remain elusive. Since HIV-1 infects and manipulates important effectors of both the innate and adaptive immune system, identifying modulations of the host cell systems in humans durin...
ORGANISM(S): Homo sapiens (Human) 
2017-02-28 | PXD005234 | Pride
Cd4 t cell Hiv Swath 
ProteomicsSWATH analysis of 1433B_HUMAN affinity purifications from HEK293 cells after time course treatment with IGF1
Protein complexes and protein interaction networks are essential mediators of most biological functions. Complexes supporting transient functions such as signal transduction processes are frequently subject to dynamic remodeling. Currently, the majority of studies into the composition of protein com...
ORGANISM(S): Homo sapiens (Human) 
2013-09-25 | PXD000343 | Pride
Ap-ms Ap-swath Quantitative interaction proteomics Affinity purificaiton 
UnknownTranscriptome analysis reveals activation of detoxification and defense mechanisms in smoke-exposed Merlot grape (Vitis vinifera) berries.
Not available
S-EPMC11393342 | biostudies-literature
TranscriptomicsTime course RNA-seq of Mycobacterium tuberculosis exposed to nitric oxide.
Mycobacterium tuberculosis is an intracellular human pathogen with the ability to resist and adapt to many adverse conditions it encounters upon infection. Among these, overcoming the production of nitric oxide by macrophages could be key for M. tuberculosis success. We have challenged M. tuberculo...
ORGANISM(S): Mycobacterium tuberculosis H37Rv 
2017-08-29 | E-MTAB-5557 | biostudies-arrayexpress
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