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TranscriptomicsExpression data at each site in colon cancer
Colon cancer invade to depper layer and the expression of major molecules at cancer front change. But the screening of expression changing at cancer front has not be adequtely clarified. We compared gene expression at cancer front with it at cancer center. We got cancer cells from cancer front(F) an...
ORGANISM(S): Homo sapiens 
2016-01-06 | E-GEOD-65480 | biostudies-arrayexpress
ProteomicsComparative proteomics analysis identifies Cdc42-Cdc42BPA signaling as prognostic biomarker and therapeutic target for colon cancer invasion
Eight rounds of selection of cancer cells invading through matrigel-coated chamber was performed to obtain highly invasive colon cancer sublines HCT116-I8 and RKO-I8. Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) technology was used to identify the differently expressed proteins and...
ORGANISM(S): Homo sapiens (Human) 
2017-11-06 | PXD007931 | Pride
Silac proteomics，cdc42 Cdc42bpa Colon cancer invasion Prognostic biomarker Targeted therapy 
TranscriptomicsNFAT transcriptional activity is associated with metastatic capacity in colon cancer
Colorectal carcinoma is the third leading cause of cancer-related death in the United States. In order to understand the mechanism/signaling pathways responsible for invasion, migration and metastasis in colorectal cancer, we developed an integrative and comparative genetic approach to infer transcr...
ORGANISM(S): Homo sapiens 
2014-10-21 | E-GEOD-38832 | biostudies-arrayexpress
TranscriptomicsExpression profiling of stage IIA/MSS colon cancers from whole tumor and invasion front sampling
The goal was to identify gene expression signatures predictive of early relapse among stage IIA/MSS colon cancer patients. A secondary question addressed was whether the invasion front profiles could generate a competitive signature. 39 whole tumor and 35 matched invasion front profiles were generat...
ORGANISM(S): Homo sapiens 
2024-03-25 | E-MTAB-13695 | biostudies-arrayexpress
MetabolomicsVisceral obesity-Induced METTL27 regulation of the FABP5/PPARD/CPT1A axis in promoting colorectal cancer progression

The incidence of obesity and colorectal cancer (CRC) is rising annually. Obesity, particularly visceral obesity, poses a serious health threat, yet the association of obesity with CRC progression, as well as the role of visceral obesity, remains debated. This study analyzed 394 CRC patients ...

2025-10-06 | MTBLS13095 | MetaboLights
ProteomicsHeat Shock Factor 1-dependent extraceHeat Shock Factor 1-dependent extracellular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancerllular matrix remodeling mediates the transition from chronic intestinal inflammation to colon cancer
Chronic inflammation underlies tumor initiation, progression, invasion, and metastasis. In the colon, long-term exposure to chronic inflammation drives colitis associated colon cancer (CAC) in patients with inflammatory bowel disease (IBD). While the causal and clinical links between chronic inflamm...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-05 | PXD022207 | Pride
Ecm Cancer Hsf1 Cancer associated fibroblasts Colon cancer Tumor microenvironmnet 
TranscriptomicsTrancriptomic profiling of HCT116 colon cancer cells with or without PBRM1 knock-down by RNAi
To investigate the influence of PBRM1 on gene expression, we performed RNA-seq in HCT116 colon cancer cells with or without PBRM1 knock-down by RNAi (both shRNA and siRNA approaches were used), and identified differentially expressed genes in PBRM1 knock-down cells compared to control cells, which s...
ORGANISM(S): Homo sapiens 
2018-01-30 | E-MTAB-5566 | biostudies-arrayexpress
TranscriptomicsHuman Subperitoneal Fibroblasts and Cancer Cell Interaction Creates Microenvironment Enhancing Tumor Progression and Metastasis
Fibroblasts isolated from human colon submucosal and subperitoneal layer were stimulated by colon cancer cell line (DLD-1) cultured medium. Peritoneal invasion in colon cancer is an important prognostic factor, and the fibrosis with α-SMA was a significant pathological feature of the cancer microenv...
ORGANISM(S): Homo sapiens 
2014-02-20 | E-GEOD-53059 | biostudies-arrayexpress
GenomicsPhenotypic plasticity underlies local invasion and distant metastasis in colon cancer (Bulk RNA-Seq)
Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer (Bulk RNA-Seq)
PRJNA647892 | ENA
GenomicsPhenotypic plasticity underlies local invasion and distant metastasis in colon cancer (Single cell RNA-Seq)
Phenotypic plasticity underlies local invasion and distant metastasis in colon cancer (Single cell RNA-Seq)
PRJNA647895 | ENA
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