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ProteomicsHX-MS data: Feedback regulation of heat shock factor 1 (Hsf1) activity by Hsp70-mediated trimer unzipping and dissociation from DNA
The heat shock response is a universal transcriptional response to proteotoxic stress orchestrated by heat shock transcription factor Hsf1 in all eukaryotic cells. Despite over 40 years of intense research, the mechanism of HSF1 activity regulation remains poorly understood at a molecular level. In ...
ORGANISM(S): Homo sapiens (Human) 
2020-06-22 | PXD017406 | Pride
Heat shock factor Entropic pulling Hsf1 Attenuation Heat shock response Hsp70 Dnajb1/hdj1 Dna binding 
TranscriptomicsHSF1 regulates transcription of sex-chromosomal multicopy genes during post-meiotic repression
Mapping of in vivo targets for HSF1 by using mammalian tissue material in a global ChIP-chip promoter screen. Chromatin was isolated from three wild-type (WT) mouse testes, crosslinked and sonicated into fragments of 100-500 bp, and the quality of the DNA was controlled before the immunoprecipitatio...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-22492 | biostudies-arrayexpress
ProteomicsExcess protein synthesis, denatured proteins or molecular crowding spontaneously induce HSF1 trimerisation and activation
Stress responses are a key feature of normal physiology and are usurped by cancer cells to ensure enhanced protein synthesis for growth, to compensate for genomic instability, and to protect cancer cells from therapy induced stress. Heat shock factor-1 (HSF1) is a major stress-response transcription...
ORGANISM(S): Homo sapiens (Human) 
2024-08-14 | PXD037662 | Pride
Lc-msms Hsf1 Stress Hsp70 Hsp90 Crowding Hdx-ms Protein folding 
TranscriptomicsTranscription profiling of Candida albicans wild type and conditional mutant hsf1/TET-HSF1
To investigate the role of HSF1 in Candida albicans
ORGANISM(S): Candida albicans 
2010-01-05 | E-MEXP-1369 | biostudies-arrayexpress
GenomicsHSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers
This SuperSeries is composed of the following subset Series: GSE38232: HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [gene expression] GSE38901: HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human...
ORGANISM(S): Homo sapiens 
2012-08-06 | E-GEOD-38912 | biostudies-arrayexpress
ProteomicsStriatal Synaptoproteomics of HSF1 Conditional Knock Out in the Adult Mouse Brain
This project examined the effects of the conditional knockout of the transcription factor HSF1 in striatal neurons on the proteome of synapses. HSF1 is a prolific stress-responsive transcription factor, but it has been indicated in regulating synapse stability under physiological conditions in the m...
ORGANISM(S): Mus musculus (Mouse) 
2026-08-20 | PXD082176 | Pride
Synaptosomes Hsf1 Brain Striatum 
TranscriptomicsEffect of 4-Hydroxynonenal on gene expression. Comparison of HSF1-siRNA silenced vs control cells
4-Hydroxynonenal (HNE), a cytotoxic and diffusible electrophile generated by the spontaneous decomposition of oxidized lipids, has a suspected role in neurodegenerative and inflammatory disease processes. In addition to promoting cell death, elevated levels of HNE lead to the engagement of cytoprote...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-12762 | biostudies-arrayexpress
GenomicsHSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers [ChIP-Seq]
Heat-Shock Factor 1 (HSF1), master regulator of the heat-shock response, facilitates malignant transformation, cancer cell survival and proliferation in model systems. The common assumption is that these effects are mediated through regulation of heat-shock protein (HSP) expression. However, the tra...
ORGANISM(S): Homo sapiens 
2012-08-07 | E-GEOD-38901 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Candida albicans wildtype and hsf1 mutant cells after heatstress
effect of heatstress on wildtype and hsf1 mutant cells
ORGANISM(S): Candida albicans 
2009-12-17 | E-MEXP-2044 | biostudies-arrayexpress
TranscriptomicsExpression of heat shock factor 1 (HSF1) knock down (KD) in hepatocellular carcinoma (HCC) cells results in characteristic changes in gene expression profiles.
Analysis of HSF1-down regulation of HCC cells at gene expression level. Results provide important information of genes involved in HSF1, such as liver proliferation, apoptosis, stress response, metabolism, these genes were up- or down-regulated. Total RNA obtained from HSF1-KD KYN2 (HCC) cells and H...
ORGANISM(S): Homo sapiens 
2013-06-07 | E-GEOD-47693 | biostudies-arrayexpress
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