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ProteomicsHX-MS data: Feedback regulation of heat shock factor 1 (Hsf1) activity by Hsp70-mediated trimer unzipping and dissociation from DNA
The heat shock response is a universal transcriptional response to proteotoxic stress orchestrated by heat shock transcription factor Hsf1 in all eukaryotic cells. Despite over 40 years of intense research, the mechanism of HSF1 activity regulation remains poorly understood at a molecular level. In ...
ORGANISM(S): Homo sapiens (Human) 
2020-06-22 | PXD017406 | Pride
Heat shock factor Entropic pulling Hsf1 Attenuation Heat shock response Hsp70 Dnajb1/hdj1 Dna binding 
UnknownHsp40 proteins phase separate to chaperone the assembly and maintenance of membraneless organelles.
Not available
S-EPMC7733851 | biostudies-literature
UnknownKnock-down of Hdj2/DNAJA1 co-chaperone results in an unexpected burst of tumorigenicity of C6 glioblastoma cells.
Not available
S-EPMC5008343 | biostudies-literature
TranscriptomicsGene expression profiles mas5D, ssa2D, hsf1-overexpressing and heat-stressed wild type Schizosaccharomyces pombe cells
The cells with the impaired Hsp40/Hsp70 chaperone complex Mas5/Ssa2 exhibit a transriptional response that is simillar to that of cells with the elevated levels of the heat-shock factor 1 (Hsf1) or heat-stressed wild type fission yeast cells A total of 6 experimental conditions has been analyzed inc...
ORGANISM(S): Schizosaccharomyces pombe 
2013-09-20 | E-GEOD-50156 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human leukemia U937 cells response to mild hypothermia
The rationale underlying hyperthermia is the fact that temperatures over 42.5ËšC are highly cytotoxic to tumor cells. On the other hand, although mild hyperthermia at a range from 39 to 41ËšC alone did not induce cytotoxicity in tumor cells, mild hyperthermia is reported to show a synergism with rad...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-10043 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Francisella tularensis LVS carrying plasmid pFNLTP6-gro or pFNLTP-gro-0851 (expressing rpoH) grown to mid exponential phase
F. tularensis LVS carrying plasmid pFNLTP6-gro or pFNLTP-gro-0851 (expressing rpoH) were grown to mid exponential phase in Schaedler + vitamin K3 medium and RNA isolated.
ORGANISM(S): Francisella tularensis 
2009-07-01 | E-MEXP-2048 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Francisella tularensis LVS after heat shock
Effect of temperature upshift at 44°C for 30 minutes on transcription in Francisella tularensis LVS
ORGANISM(S): Francisella tularensis 
2009-07-01 | E-MEXP-2037 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of moise cochlear after noise-induced changes in strains differing in their susceptibility to noise damage
The molecular mechanisms underlying the great differences in susceptibility to noise-induced hearing loss (NIHL) exhibited by both humans and laboratory animals are unknown. Using microarray technology, the present study demonstrates that the effects of noise overexposure on the expression of molec...
ORGANISM(S): Mus musculus 
2008-10-25 | E-GEOD-8342 | biostudies-arrayexpress
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