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ProteomicsInvestigating the effect of molecular crowding agents on protein stability in a bacterial proteome
Molecular crowding refers to the restriction of space available for molecular mobility in solution due to the presence of other macromolecules. Crowding can influence biological phenomena such as protein stability and folding, diffusion, enzyme kinetics, molecular interactions, and phase separation....
ORGANISM(S): Bacteria Cupriavidus necator (strain ATCC 17699 / H16 / DSM 428 / Stanier 337) (Ralstonia eutropha) 
2026-02-23 | PXD067043 | Pride
Thermal proteomics  cupriavidus necator  macromolecular crowding 
GenomicsSpatiotemporal lineage derepression by cell crowding-induced ETV4 inactivation
Spatiotemporal lineage derepression by cell crowding-induced ETV4 inactivation
PRJNA761710 | ENA
TranscriptomicsProlonged Crowding Drives Cancer Cell Invasiveness
Our study found that prolonged crowding drives cancer cell invasiveness with memory retention. To further characterize gene expression regulated by prolonged crowding, RNA sequencing was performed in crowding-primed cells (20 days) followed by sparse culture for different times (0, 1, 3, or 10 days)...
ORGANISM(S): Homo sapiens 
2024-12-01 | GSE281770 | GEO
ProteomicsExcess protein synthesis, denatured proteins or molecular crowding spontaneously induce HSF1 trimerisation and activation
Stress responses are a key feature of normal physiology and are usurped by cancer cells to ensure enhanced protein synthesis for growth, to compensate for genomic instability, and to protect cancer cells from therapy induced stress. Heat shock factor-1 (HSF1) is a major stress-response transcription...
ORGANISM(S): Homo sapiens (Human) 
2024-08-14 | PXD037662 | Pride
Lc-msms Hsf1 Stress Hsp70 Hsp90 Crowding Hdx-ms Protein folding 
GenomicsResponses to crowding stress in Atlantic salmon reared in different aquaculture systems
Responses to crowding stress in Atlantic salmon reared in different aquaculture systems
PRJNA725241 | ENA
GenomicsPhysical Crowding in 3D Niche Regulates NSCs of Cell Junction and Differentiation
Physical Crowding in 3D Niche Regulates NSCs of Cell Junction and Differentiation
PRJNA1248518 | ENA
TranscriptomicsSpatiotemporal lineage derepression by cell crowding-induced ETV4 inactivation
All extant amniotes employ a single-layered epithelium of epiblasts as a starting material for gastrulation, suggesting the necessity of the epithelial structure for three germ layer derivation. Using a human embryonic stem cell (hESC) epithelium as a model system, we found that local epithelial cro...
ORGANISM(S): Homo sapiens 
2024-03-12 | GSE183702 | GEO
TranscriptomicsPhysical Crowding in 3D Niche Regulates NSCs of Cell Junction and Differentiation
Neural stem cells (NSCs) maintain central nervous system (CNS) homeostasis through self-renewal and differentiation into neurons and glia. While physical crowding dynamically regulates NSCs niches during CNS development, yet its role in regulating NSCs fate remains unclear. Herein, we systematically...
ORGANISM(S): Rattus norvegicus 
2026-02-25 | GSE294177 | GEO
TranscriptomicsSweet corn: low- vs. high-yielding hybrids
Transcriptional profiling of sweet corn plant density (crowding stress) tolerance influencing yield. Tolerance to crowding stress has played a crucial role in improving agronomic productivity in field corn; however, commercial sweet corn hybrids vary greatly in crowding stress tolerance. The experim...
ORGANISM(S): Zea mays 
2016-01-05 | E-GEOD-73435 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Antirrhinum majus inflorescence meristems grown under control and crowding conditions
Investigation of gene expression level changes as a result of crowding growth conditions.
ORGANISM(S): Antirrhinum majus 
2015-09-10 | GSE72818 | GEO
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