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ProteomicsComparative proteomics analysis identifies Cdc42-Cdc42BPA signaling as prognostic biomarker and therapeutic target for colon cancer invasion
Eight rounds of selection of cancer cells invading through matrigel-coated chamber was performed to obtain highly invasive colon cancer sublines HCT116-I8 and RKO-I8. Stable Isotope Labeling by Amino Acids in Cell Culture (SILAC) technology was used to identify the differently expressed proteins and...
ORGANISM(S): Homo sapiens (Human) 
2017-11-06 | PXD007931 | Pride
Silac proteomics，cdc42 Cdc42bpa Colon cancer invasion Prognostic biomarker Targeted therapy 
GenomicsGene expression profiling of MDA231 cells depleted of MRCKalpha (CDC42BPA) and MRCKbeta (CDC42BPB)
Gene expression profiling of MDA231 cells depleted of MRCKalpha (CDC42BPA) and MRCKbeta (CDC42BPB)
PRJNA714883 | ENA
TranscriptomicsGene expression profiling of MDA231 cells depleted of MRCKalpha (CDC42BPA) and MRCKbeta (CDC42BPB)
Aim: The MRCK family of kinases (namely MRCKalpha and MRCKbeta) are downstream effectors of the Rho GTPase signaling pathways with roles in mediating cell migration via regulating the actin cytoskeleon. As such, it is thought that the MRCKs might also be involved in promoting cancer cell invasion or...
ORGANISM(S): Homo sapiens 
2021-03-17 | GSE169000 | GEO
ProteomicsIdentification of MRCKA as an integral component of ovarian cancer signaling and a therapeutic target
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSOC...
ORGANISM(S): Homo sapiens (Human) 
2020-02-19 | PXD015781 | Pride
Human Mrcka High grade serous ovarian carcinoma Cdc42bpa 
ProteomicsIdentification of MRCKA as an integral component of ovarian cancer signaling and a therapeutic target
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSOC...
ORGANISM(S): Homo sapiens (Human) 
2020-02-19 | PXD015782 | Pride
Human Mrcka High grade serous ovarian carcinoma Cdc42bpa 
ProteomicsIdentification of MRCKA as an integral component of ovarian cancer signaling and a therapeutic target
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSOC...
ORGANISM(S): Homo sapiens (Human) 
2020-02-19 | PXD015849 | Pride
Human Mrcka High grade serous ovarian carcinoma Cdc42bpa 
ProteomicsIdentification of MRCKA as an integral component of ovarian cancer signaling and a therapeutic target
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSOC...
ORGANISM(S): Homo sapiens (Human) 
2020-02-19 | PXD015783 | Pride
Human High-grade serous ovarian carcinoma Mrcka Cdc42bpa 
UnknownIntegrated genomics and metabolomics analysis revealed the metabolic mechanisms by which genetic variations affect the growth performance of local chickens.
Not available
S-EPMC12870779 | biostudies-literature
UnknownDysbindin-1 contributes to prefrontal cortical dendritic arbor pathology in schizophrenia.
Not available
S-EPMC6230503 | biostudies-literature
UnknownRole of cytoskeleton-related proteins in the acrosome reaction of Eriocheir sinensis spermatozoa.
Not available
S-EPMC9926718 | biostudies-literature
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