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ProteomicsIdentification of MRCKA as an integral component of ovarian cancer signaling and a therapeutic target
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSOC...
ORGANISM(S): Homo sapiens (Human) 
2020-02-19 | PXD015782 | Pride
Human Mrcka High grade serous ovarian carcinoma Cdc42bpa 
ProteomicsIdentification of MRCKA as an integral component of ovarian cancer signaling and a therapeutic target
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSOC...
ORGANISM(S): Homo sapiens (Human) 
2020-02-19 | PXD015849 | Pride
Human Mrcka High grade serous ovarian carcinoma Cdc42bpa 
ProteomicsIdentification of MRCKA as an integral component of ovarian cancer signaling and a therapeutic target
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSOC...
ORGANISM(S): Homo sapiens (Human) 
2020-02-19 | PXD015783 | Pride
Human High-grade serous ovarian carcinoma Mrcka Cdc42bpa 
UnknownFunctional proteomics interrogation of the kinome identifies MRCKA as a therapeutic target in high-grade serous ovarian carcinoma.
Not available
S-EPMC7294993 | biostudies-literature
ProteomicsIdentification of MRCKA as an integral component of ovarian cancer signaling and a therapeutic target
High-grade serous ovarian carcinoma (HGSOC) is the most lethal gynecological cancer with few effective targeted therapies. HGSOC tumors exhibit genomic instability with frequent alterations in the protein kinome; however, only a small fraction of the kinome has been therapeutically targeted in HGSOC...
ORGANISM(S): Homo sapiens (Human) 
2020-02-19 | PXD015781 | Pride
Human Mrcka High grade serous ovarian carcinoma Cdc42bpa 
ProteomicsDiscovery of Chirally-dependent Protein O-2-Hydroxyglutarylation
Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are common in multiple types of human cancer and cause accumulation of the oncometabolite D-2-hydroxyglutarate (D2HG), which promotes tumor progression by noncovalently inhibiting α-ketoglutarate–dependent enzymes. Here we discovered covalent O...
ORGANISM(S): Homo sapiens (Human) 
2026-03-18 | PXD072530 | Pride
D2hg L2hg Ptm O-2-hydroxyglutarylation 
UnknownDiscovery of Chirally-dependent Protein O-2-Hydroxyglutarylation by D2HG and L2HG.
Not available
S-EPMC11838245 | biostudies-literature
ProteomicsLarge-scale Discovery of Substrates of the Human Kinome (MRCKa) [Reanalysis: JPST000508]
Kinase -networks are important for cellular signal transduction. Despite tremendous efforts to uncover these signaling pathways, huge numbers of uncharacterized phosphosites still remain in the human proteome. Because of the transient nature of kinase-substrate interactions in vivo, it is almost imp...
ORGANISM(S): Homo Sapiens (human) 
2024-02-21 | RPXD049626 | JPOST Repository
ProteomicsDiscovery of Chiral D2HG and L2HG mediated Protein O-2-Hydroxyglutarylation
Oncometabolites including D-2-hydroxyglutarate (D2HG) and L2HG have come under the spotlight due to their roles in promoting tumorigenesis. These oncometabolites dysregulate growth-signalling pathways by noncovalently interacting with key regulators. However, it is unclear whether D/L 2HG influence ...
ORGANISM(S): Homo Sapiens (human) 
2025-01-25 | PXD059758 | JPOST Repository
ProteomicsDiscovery of Chirally-dependent Protein O-2-Hydroxyglutarylation by D2HG and L2HG
Oncometabolites including D-2-hydroxyglutarate (D2HG) and L2HG have come under the spotlight due to their roles in promoting tumorigenesis. These oncometabolites dysregulate growth-signalling pathways by noncovalently interacting with key regulators. However, it is unclear whether D/L 2HG influence ...
ORGANISM(S): Homo Sapiens (human) 
2025-12-24 | PXD069585 | JPOST Repository
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