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GenomicsGene expression profile of HCT116 and HT29 cells treated with D/L2HG
Gene expression profile of HCT116 and HT29 cells treated with D/L2HG
PRJNA864601 | ENA
ProteomicsDiscovery of Chirally-dependent Protein O-2-Hydroxyglutarylation
Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are common in multiple types of human cancer and cause accumulation of the oncometabolite D-2-hydroxyglutarate (D2HG), which promotes tumor progression by noncovalently inhibiting α-ketoglutarate–dependent enzymes. Here we discovered covalent O...
ORGANISM(S): Homo sapiens (Human) 
2026-03-18 | PXD072530 | Pride
D2hg L2hg Ptm O-2-hydroxyglutarylation 
UnknownDiscovery of Chirally-dependent Protein O-2-Hydroxyglutarylation by D2HG and L2HG.
Not available
S-EPMC11838245 | biostudies-literature
ProteomicsDiscovery of Chiral D2HG and L2HG mediated Protein O-2-Hydroxyglutarylation
Oncometabolites including D-2-hydroxyglutarate (D2HG) and L2HG have come under the spotlight due to their roles in promoting tumorigenesis. These oncometabolites dysregulate growth-signalling pathways by noncovalently interacting with key regulators. However, it is unclear whether D/L 2HG influence ...
ORGANISM(S): Homo Sapiens (human) 
2025-01-25 | PXD059758 | JPOST Repository
ProteomicsDiscovery of Chirally-dependent Protein O-2-Hydroxyglutarylation by D2HG and L2HG
Oncometabolites including D-2-hydroxyglutarate (D2HG) and L2HG have come under the spotlight due to their roles in promoting tumorigenesis. These oncometabolites dysregulate growth-signalling pathways by noncovalently interacting with key regulators. However, it is unclear whether D/L 2HG influence ...
ORGANISM(S): Homo Sapiens (human) 
2025-12-24 | PXD069585 | JPOST Repository
GenomicsL-2-hydroxyglutarate modulates ferroptosis through Nrf2/Slc7a11 and Atf4/Chac1 axes in hepatocellular carcinoma
Liver tumors undergo profound metabolic reprogramming to support survival, proliferation, and metastasis. Through a metabolic library screen combined with network-level integration of transcriptomic and metabolomic data, we identified a regulatory role of L-2-hydroxyglutarate dehydrogenase (L2HGDH) ...
ORGANISM(S): Homo sapiens 
2025-07-26 | GSE302217 | GEO
TranscriptomicsNrf2-regulated L-2-hydroxyglutarate sensitizes erythroid cells to ferroptosis in sickle cell disease
SCD had hemolysis with elevated levels of heme and iron, which induced ferroptosis. Here, we found Nrf2 knockout in SCD mice accumulated the levels of the metabolite L-2-hydroxyglutarate (L2HG), which impaired ferroptosis stress response to exacerbate SCD symptom. Mechanistically, L2HG was found to ...
ORGANISM(S): Mus musculus 
2021-11-19 | GSE188695 | GEO
GenomicsNrf2-regulated L-2-hydroxyglutarate sensitizes erythroid cells to ferroptosis in sickle cell disease [ChIP]
SCD had hemolysis with elevated levels of heme and iron, which induced ferroptosis. Here, we found Nrf2 knockout in SCD mice accumulated the levels of the metabolite L-2-hydroxyglutarate (L2HG), which impaired ferroptosis stress response to exacerbate SCD symptom. Mechanistically, L2HG was found to ...
ORGANISM(S): Homo sapiens 
2023-03-02 | GSE225966 | GEO
GenomicsNrf2-regulated L-2-hydroxyglutarate sensitizes erythroid cells to ferroptosis in sickle cell disease [ChIP-seq]
SCD had hemolysis with elevated levels of heme and iron, which induced ferroptosis. Here, we found Nrf2 knockout in SCD mice accumulated the levels of the metabolite L-2-hydroxyglutarate (L2HG), which impaired ferroptosis stress response to exacerbate SCD symptom. Mechanistically, L2HG was found to ...
ORGANISM(S): Mus musculus 
2023-03-02 | GSE223911 | GEO
TranscriptomicsNrf2 ablation abolishes liver tumorigenesis by suppressing L-2-hydroxyglutarate-driven regulation of ferroptosis in a spontaneous liver tumor model induced by hepatic Tsc1 deletion
The metabolite L-2-hydroxyglutarate (L2HG) regulates liver tumor development through both anti- and pro-ferroptotic mechanisms, mediated via the Nrf2/Slc7a11 and Atf4/Chac1 signaling axes. To investigate the essential role of Nrf2 in L2HG-driven ferroptosis regulation, we analyzed gene expression pr...
ORGANISM(S): Mus musculus 
2025-07-26 | GSE301997 | GEO
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