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ProteomicsDiscovery of Chirally-dependent Protein O-2-Hydroxyglutarylation
Mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 are common in multiple types of human cancer and cause accumulation of the oncometabolite D-2-hydroxyglutarate (D2HG), which promotes tumor progression by noncovalently inhibiting α-ketoglutarate–dependent enzymes. Here we discovered covalent O...
ORGANISM(S): Homo sapiens (Human) 
2026-03-18 | PXD072530 | Pride
D2hg L2hg Ptm O-2-hydroxyglutarylation 
UnknownDiscovery of Chirally-dependent Protein O-2-Hydroxyglutarylation by D2HG and L2HG.
Not available
S-EPMC11838245 | biostudies-literature
UnknownD2HGDH-mediated D2HG catabolism enhances the anti-tumor activities of CAR-T cells in an immunosuppressive microenvironment.
Not available
S-EPMC8899596 | biostudies-literature
ProteomicsDiscovery of Chiral D2HG and L2HG mediated Protein O-2-Hydroxyglutarylation
Oncometabolites including D-2-hydroxyglutarate (D2HG) and L2HG have come under the spotlight due to their roles in promoting tumorigenesis. These oncometabolites dysregulate growth-signalling pathways by noncovalently interacting with key regulators. However, it is unclear whether D/L 2HG influence ...
ORGANISM(S): Homo Sapiens (human) 
2025-01-25 | PXD059758 | JPOST Repository
ProteomicsDiscovery of Chirally-dependent Protein O-2-Hydroxyglutarylation by D2HG and L2HG
Oncometabolites including D-2-hydroxyglutarate (D2HG) and L2HG have come under the spotlight due to their roles in promoting tumorigenesis. These oncometabolites dysregulate growth-signalling pathways by noncovalently interacting with key regulators. However, it is unclear whether D/L 2HG influence ...
ORGANISM(S): Homo Sapiens (human) 
2025-12-24 | PXD069585 | JPOST Repository
Methylation profilingCatalytically distinct metabolic enzyme isocitrate dehydrogenase 1 mutants tune phenotype severity in tumor models [BiSulfite-seq]
Mutations in isocitrate dehydrogenase 1 (IDH1) impart a neomorphic reaction that produces D-2-hydroxyglutarate (D2HG), which can inhibit DNA demethylases to drive tumorigenesis. Mutations affect residue R132 and display distinct catalytic profiles for D2HG production. We show that catalytic efficien...
ORGANISM(S): Mus musculus 
2025-04-11 | GSE276110 | GEO
TranscriptomicsCatalytically distinct metabolic enzyme isocitrate dehydrogenase 1 mutants tune phenotype severity in tumor models
Mutations in isocitrate dehydrogenase 1 (IDH1) impart a neomorphic reaction that produces D-2-hydroxyglutarate (D2HG), which can inhibit DNA demethylases to drive tumorigenesis. Mutations affect residue R132 and display distinct catalytic profiles for D2HG production. We show that catalytic efficien...
ORGANISM(S): Mus musculus 
2025-04-11 | GSE276109 | GEO
UnknownModeling the diffusion of D-2-hydroxyglutarate from IDH1 mutant gliomas in the central nervous system.
Not available
S-EPMC6071651 | biostudies-literature
UnknownSingle-cell profiling of D-2-hydroxyglutarate using surface-immobilized resazurin analogs.
Not available
S-EPMC8321683 | biostudies-literature
UnknownIntracerebral Distribution of the Oncometabolite d-2-Hydroxyglutarate in Mice Bearing Mutant Isocitrate Dehydrogenase Brain Tumors: Implications for Tumorigenesis.
Not available
S-EPMC5057413 | biostudies-literature
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