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MetabolomicsExtracts from sweet sorghum (Sorghum bicolor), a feedstock for biorefining, suppressed proliferation and elevated apoptosis in human colon cancer stem cells via suppression of Wnt/beta-catenin signaling pathway
In colorectal cancer, p53 is commonly inactivated, associated with chemo-resistance, and marks the transition from non-invasive to invasive disease. Cancers, including colorectal cancer, are thought to be diseases of aberrant stem cell populations, as stem cells are able to self-renew, making them l...
2014-05-01 | MTBLS69 | MetaboLights
MetabolomicsFatty acid oxidation protects cancer cells from apoptosis through increasing mitochondrial membrane lipids

Overcoming resistance to chemotherapies remains a major unmet need for cancers such as triple negative breast cancer (TNBC). Therefore, mechanistic studies to provide insight for drug development are urgently needed to overcome TNBC therapy resistance. Recently, an important role of fatty acid β-...

2022-05-31 | MTBLS4709 | MetaboLights
MetabolomicsLactate controls cancer stemness and plasticity through epigenetic regulation.

Tumours arise from uncontrolled cell proliferation driven by mutations in genes that regulate stem cell renewal and differentiation. Intestinal tumours, however, retain some hierarchical organization, maintaining both cancer stem cells (CSCs) and cancer differentiated cells (CDCs). This heterogen...

2025-05-28 | MTBLS11849 | MetaboLights
TranscriptomicsTranscription profiling of methotrexate-treated human colon cancer C85 cells
The experiment was aimed at identification of genes whose expression is upregulated in human colon cancer C85 cells during the process of establishment of methotrexate-induced senescence.
ORGANISM(S): Homo sapiens 
2011-08-23 | E-MEXP-3018 | biostudies-arrayexpress
TranscriptomicsExpression data at each site in colon cancer
Colon cancer invade to depper layer and the expression of major molecules at cancer front change. But the screening of expression changing at cancer front has not be adequtely clarified. We compared gene expression at cancer front with it at cancer center. We got cancer cells from cancer front(F) an...
ORGANISM(S): Homo sapiens 
2016-01-06 | E-GEOD-65480 | biostudies-arrayexpress
TranscriptomicsExpression data from TOP-GFP sorted colon cancer cells
Colon cancers typically contain tumor cell populations with differential WNT signaling activity. Colon cancer cells with high WNT-activity have been attributed increase tumorigenic potential and stem cell characteristics. We extracted tumor cells with differential WNT activity using fluorescent repo...
ORGANISM(S): Homo sapiens 
2012-02-16 | E-GEOD-32408 | biostudies-arrayexpress
ProteomicsColon cancer stem cell over-expressing TAp63α
p63, a member of p53 family, is transcribed in different variants, containing (TA) or lacking (N) the N-terminal transactivation domain. Although the proteins of p53 family share high sequence and structural similarities, distinct functions for p63 are emerging. Here we provided a quantitative prote...
ORGANISM(S): Homo sapiens (Human) 
2014-03-17 | PXD000768 | Pride
Lc-msms Stable isotope dimethyl labeling Colon cancer stem cells P63 
ProteomicsColon cancer stem cell over-expressing ΔNp63α
p63, a member of p53 family, is transcribed in different variants, containing (TA) or lacking (ΔN) the N-terminal transactivation domain. Although the proteins of p53 family share high sequence and structural similarities, distinct functions for p63 are emerging. Here we provided a quantitative prot...
ORGANISM(S): Homo sapiens (Human) 
2014-03-17 | PXD000769 | Pride
Lc-msms Stable isotope dimethyl labeling Colon cancer stem cells P63 
TranscriptomicsGene expression in colon cancer stem cells (CSC) cultures identified by Wnt signaling levels
Primary colon CSC cultures were transduced with a Wnt responsive construct (TOP-GFP) and were single cell cloned. 10% highest and lowest TOP-GFP cell fractions were FACS sorted and arrayed. Primary colon CSC cultures with a responsive construct (TOP-GFP): high and low TOP-GFP cell fractions. 4 sampl...
ORGANISM(S): Homo sapiens 
2009-12-01 | E-GEOD-17375 | biostudies-arrayexpress
TranscriptomicsPRPF6 regulated alternative splicing in colon cancer cell lines
PRPF6, an RNA binding component of the pre-mRNA spliceosome, is an essential driver of oncogenesis in colon cancer. PRPF6 is both amplified and overexpressed in colon cancer and cells with high PRPF6 levels are sensitive to its loss. Here we investigate alternative splicing changes in colon cancer ...
ORGANISM(S): Homo sapiens 
2014-06-18 | E-GEOD-56846 | biostudies-arrayexpress
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