Sort   by:  
 Page size 
TranscriptomicsAll exon array expression data in normal colon and primary colon cancer lines [expression]
Cancer is characterized by gene expression aberrations. Studies have largely focused on coding sequences and promoters, despite the fact that distal regulatory elements play a central role in controlling transcription patterns. Here we utilize the histone mark H3K4me1 to analyze gain and loss of en...
ORGANISM(S): Homo sapiens 
2012-04-15 | E-GEOD-36400 | biostudies-arrayexpress
GenomicsEpigenomic enhancer profiling defines a signature of colon cancer [ChIP-seq]
Cancer is characterized by gene expression aberrations. Studies have largely focused on coding sequences and promoters, despite the fact that distal regulatory elements play a central role in controlling transcription patterns.  Here we utilize the histone mark H3K4me1 to analyze gain and loss of en...
ORGANISM(S): Homo sapiens 
2012-04-15 | E-GEOD-36204 | biostudies-arrayexpress
ProteomicsLoss of colonic primary cilia promotes inflammation and carcinogenesis
Primary cilia (PC) are important signaling hubs in cells and we explored their role in colorectal cancer (CRC) and colitis. In the colon we found PC to be mostly present on different subtypes of fibroblasts and exposure of mice to either chemically induced colitis-associated colon carcinogenesis (CA...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-29 | PXD033440 | Pride
Colon carcinogenesis Inflammation Primary cilia Colonic fibroblasts Colitis 
TranscriptomicsEpigenomic enhancer profiling defines a signature of colon cancer
This SuperSeries is composed of the following subset Series: GSE36204: Epigenomic enhancer profiling defines a signature of colon cancer [ChIP-seq] GSE36400: All exon array expression data in normal colon and primary colon cancer lines [expression] Refer to individual Series
ORGANISM(S): Homo sapiens 
2012-04-15 | E-GEOD-36401 | biostudies-arrayexpress
TranscriptomicsMolecular signatures of N-nitroso compounds in Caco-2 cells: implications for colon carcinogenesis
N-nitroso compounds (NOC) are genotoxic compounds and animal carcinogens, and may play a role in human cancer development. Since the gastro-intestinal tract is an important route of exposure, we hypothesize that NOC exposure targets genetic processes relevant in colon carcinogenesis. To investigate ...
ORGANISM(S): Homo sapiens 
2010-04-03 | E-GEOD-14284 | biostudies-arrayexpress
TranscriptomicsReduction of DNA methylation suppresses colon carcinogenesis through induction of tumor cell differentiation
In this study, we analyzed global gene expressions of colon tumors from DNA hypomethylated and the control mice. We found that DNA hypomethylated tumors express significantly higher levels of intestinal differentiation-related genes when compared with the control tumors. These results suggest that D...
ORGANISM(S): Mus musculus 
2015-08-05 | E-GEOD-60620 | biostudies-arrayexpress
TranscriptomicsGene expression in Tcf4Het ApcHet mouse colon tumors compared to normal colon
The Wnt/M-NM-2-catenin pathway plays multiple/diverse roles in development by regulating gene expression via Tcf/Lef DNA binding factors. Misregulation of this pathway is thought to initiate colon adenoma formation. It is controversial whether Tcf4 (Tcf7L2) functions as an oncogene or tumor suppress...
ORGANISM(S): Mus musculus 
2011-03-15 | E-GEOD-27522 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of colon mucosa after cytotoxic insult in wild type and Apc-mutated rats: possible relation with resistance to apoptosis during carcinogenesis
Gene expression profiles of the colon mucosa of wild type and PIRC rats after 1,2-dimethylhydrazine (DMH)-treatment
ORGANISM(S): Rattus norvegicus 
2016-11-03 | E-MTAB-4910 | biostudies-arrayexpress
TranscriptomicsIntegrative approach for prioritizing cancer genes in sporadic colon cancer
The current multistep carcinogenesis models of colon cancer do not fully capture the genetic heterogeneity of the disease, which is additionally complicated by the presence of passenger and driver genetic alterations. The aim of the present study was to select in the context of this significant hete...
ORGANISM(S): Homo sapiens 
2010-04-10 | E-GEOD-16125 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of human normal colon and colon cancer samples to investigate the role of miRNA involvement in colon carcinogenesis
MicroRNA (miRNA) expression profiles for colon cancers were examined to investigate the miRNA involvement in colon carcinogenesis. miRNA microarray analysis identified statistical unique profiles, which could discriminate colon cancers from noncancerous colon tissues.
ORGANISM(S): Homo sapiens 
2005-12-31 | E-TABM-46 | biostudies-arrayexpress
Sort   by:  
 Page size