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MetabolomicsDeciphering the Anti-Biofilm Mechanism of Anthraquinone-2-Carboxylic Acid Against MRSA by Comprehensive Multi-Omics Analysis

Background: Methicillin-resistant Staphylococcus aureus (MRSA) biofilms exhibit high levels of drug resistance and cause nosocomial infections in humans, thus posing a sustainable global health threat. This underscores the critical need to develop novel antibiofilm therapeutics with high efficacy...

2025-09-18 | MTBLS13012 | MetaboLights
MetabolomicsLsr2, a novel cyclic di-GMP receptor, regulate the synthesis of keto-mycolic acid and control biofilm formation in mycobacteria

Cyclic di-GMP (c-di-GMP) is a well-known second messenger that plays a key role in many physiological processes in bacteria. The synthesis of lipids is essential for bacterial biofilm formation. However, whether c-di-GMP signaling modulates the synthesis of lipid and further regulates biofilm for...

2023-12-12 | MTBLS7053 | MetaboLights
TranscriptomicsGene expression of E. coli MG1655 at attachment, colony formation and maturation during biofilm formation
Gene expression changes during biofilm formation processes were investigated. The gene expression was compared at attachment, colony formation and maturation during biofilm formation. At the same time, the gene expressions were also compared with exponential phase and stationary phase in planktonic ...
ORGANISM(S): Escherichia coli 
2009-04-01 | E-GEOD-13418 | biostudies-arrayexpress
TranscriptomicsGdpS contributes to Staphylococcus aureus biofilm formation by regulation of eDNA release
In Staphylococcus aureus, the role of the GGDEF domain containing protein GdpS remains poorly understood. Previous studies reported that gdpS mutant strains had decreased biofilm formation due to changes in icaADBC expression that were independent of cyclic-di-GMP levels. We deleted gdpS in three un...
ORGANISM(S): Staphylococcus aureus 
2014-06-30 | E-GEOD-48656 | biostudies-arrayexpress
TranscriptomicsIdentification of a complex genetic network involved in Saccharomyces cerevisiae colony morphology
When grown on solid substrates, different microorganisms often form colonies with very specific morphologies. Whereas the pioneers of microbiology often used colony morphology to discriminate between species and strains, the phenomenon has not received much recent attention. In this study, we use ...
ORGANISM(S): Saccharomyces cerevisiae 
2012-04-27 | E-GEOD-36151 | biostudies-arrayexpress
ProteomicsProteomics profiling of xanthomonas retroflexus colony variants
Plasmid conjugation is a key facilitator of horizontal gene transfer. Since plasmids often carry antibiotic resistance genes, they are crucial drivers of the world-wide rise of antibiotic resistance among pathogens. In natural, engineered and clinical environments, bacteria often grow in protective ...
ORGANISM(S): Xanthomonas retroflexus 
2024-01-26 | PXD040461 | Pride
Biofilm Colony morphology Xantomonas retroflexus Flagella 
TranscriptomicsStreptococcus pneumoniae in a biofilm are hyper-adhesive, avirulent, and when used as a killed whole-cell vaccine confers protection against lethal challenge
For Streptococcus pneumoniae, biofilms have been suggested to promote long-term colonization of the nasopharynx and contribute to the pathology of recurrent middle ear infections. To date numerous studies have investigated the contribution of specific genetic determinants for the development of pneu...
ORGANISM(S): Streptococcus pneumoniae 
2013-04-01 | E-GEOD-26976 | biostudies-arrayexpress
ProteomicsDifferences in gene expression between colony and aggregate biofilms of Clostridioides difficile revealed by proteomic profiling
The protein inventory of the anaerobic pathogen Clostridioides difficile grown in colony or aggregate biofilms was investigated in a comprehensive LC-MS/MS approach. C. difficile has a versatile metabolism and is perfectly equipped to survive and persist inside the mammalian intestine. However, know...
ORGANISM(S): Peptoclostridium difficile (strain 630) (Clostridium difficile) 
2021-07-12 | PXD022830 | Pride
Rpon signaling Clostridioides difficile Biofilm Persistence Cell surface antigens Lc-ms/ms 
TranscriptomicsPseudomonas aeruginosa PA14 wild-type vs the tpbA (PA14_13660) mutant
Microarray analysis for the biofilm cells of Pseudomonas aeruginosa PA14 wild-type vs the tpbA (PA14_13660) mutant in LB medium at 4 and 7 h at 37C Microarray analysis for the biofilm cells of Pseudomonas aeruginosa PA14 wild-type vs the tpbA (PA14_13660) mutant in LB medium at 4 and 7 h at 37C.
ORGANISM(S): Pseudomonas aeruginosa 
2009-05-23 | E-GEOD-13871 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E. coli BW25113 yncC vs wild type biofilm cells in LB 15h 37C and MG1655 yncC vs wild type colony cells in LB plates 15h 37C
E. coli K-12 BW25113 mutant strain yncC expression in biofilm cells relative to E. coli wild-type strain expression in biofilm cells. All samples were cultured in LB with glasswool at 37C for 15 hours and E. coli K-12 MG1655 mutant yncC colony cells vs wild type colony cells in LB plates 15h 37C. Qu...
ORGANISM(S): Escherichia coli 
2008-04-07 | E-GEOD-8706 | biostudies-arrayexpress
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