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MetabolomicsMetabolomic profiling of mouse colorectal tumor tissues and fecal samples following bacterial intervention
This study investigated metabolic alterations in an AOM/DSS-induced mouse colorectal tumor model following bacterial intervention with Faecalibacterium prausnitzii and Peptostreptococcus stomatis. Targeted bile acid profiling and untargeted metabolomics were performed using LC-MS on colorectal tumor...
2026-09-24 | MTBLS15620 | MetaboLights
MetabolomicsPreoperative exercise induces anti-tumor Kupffer cells to prevent surgical stress-promoted colorectal cancer liver metastasis

Kupffer cells from both Sed and PEx mice were harvested for Metabolomics. 3 weeks after tumor injection, both mice bearing MC38 tumors were sacrificed. The livers were harvested and processed into single-cell suspensions, and KCs were isolated.

2025-12-09 | MTBLS13419 | MetaboLights
MetabolomicsMetabolomics analyses of cancer tissue from patients with colorectal cancer.
The alteration of metabolism is essential for the initiation and progression of numerous types of cancer, including colorectal cancer (CRC). Metabolomics has been used to study CRC. At present, the reprogramming of the metabolism in CRC remains to be fully elucidated. In the present study, comprehen...
2024-02-08 | MTBLS8090 | MetaboLights
MetabolomicsMetabolic Drug Response Phenotyping in Colorectal Cancer Organoids by LC-QTOF-MS
As metabolic rewiring is crucial for cancer cell proliferation, metabolic phenotyping of patient-derived organoids is desirable to identify drug-induced changes and trace metabolic vulnerabilities of tumor subtypes. We established a novel protocol for metabolomic and lipidomic profiling of colorecta...
2021-10-12 | MTBLS2130 | MetaboLights
MetabolomicsThe lipid-metabolism enzyme ECI2 reduces neutrophil extracellular traps formation for colorectal cancer suppression
Abnormalities in ether lipid metabolism as well as the formation of neutrophil extracellular traps have recently been recognized as detrimental factors affecting tumorigenesis and progression. However, the role of abnormal ether lipid metabolism in colorectal cancer (CRC) evolution has not been repo...
2024-10-01 | MTBLS10323 | MetaboLights
MetabolomicsCPT2 inhibition activates selective autophagy by enhancing glycerophospholipid biosynthesis in colorectal cancer

Metabolic reprogramming is one of the hallmark events in colorectal cancer (CRC).  Tumor cells adapt to microenvironmental changes by regulating energy and biomaterial metabolism. This study identified abnormal lipid accumulation and significant downregulation of fatty acid metabolism in CRC...

2025-09-01 | MTBLS12783 | MetaboLights
MetabolomicsVisceral obesity-Induced METTL27 regulation of the FABP5/PPARD/CPT1A axis in promoting colorectal cancer progression

The incidence of obesity and colorectal cancer (CRC) is rising annually. Obesity, particularly visceral obesity, poses a serious health threat, yet the association of obesity with CRC progression, as well as the role of visceral obesity, remains debated. This study analyzed 394 CRC patients ...

2025-10-06 | MTBLS13095 | MetaboLights
MetabolomicsSingle-cell metabolic fingerprints discover a cluster of circulating tumor cells with distinct metastatic potential

Circulating tumor cells (CTCs) are recognized as direct seeds of metastasis. However, CTC count may not be the 'best' indicator of metastatic risk because their heterogeneity is generally neglected. In this study, we develop a molecular typing system to predict colorectal cancer metastasis potent...

2023-08-21 | MTBLS5028 | MetaboLights
MetabolomicsATF6 activation alters colonic lipid metabolism causing tumor-associated microbial adaptation

The induction of endoplasmic reticulum unfolded protein responses (UPRER) contributes to cancer development and progression. We recently linked microbiota-related triggers to the tumor-promoting role of signal transducer activating transcription factor 6 (ATF6) in the colon. Here we substantiate ...

2025-07-02 | MTBLS7387 | MetaboLights
MetabolomicsSpatial and Untargeted Metabolomics Define Location- and Histology-Specific Metabolic Reprogramming in Colorectal Cancer

Colorectal cancer (CRC) exhibits profound molecular heterogeneity based on primary tumor location. A comprehensive understanding of the spatially resolved metabolic differences between right-sided (RCC) and left-sided (LCC) carcinomas remains elusive. Here, to eliminate the influence of inter-ind...

2026-03-24 | MTBLS13729 | MetaboLights
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