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TranscriptomicsThe carbonic anhydrase inhibitor ethoxzolamide inhibits the Mycobacterium tuberculosis PhoPR regulon and Esx-1 secretion and attenuates virulence
The purpose of this study was to examine how ethoxzolamide modulates gene M. tuberculosis gene expression at acidic pH. We observed that ethoxzolamide downregulates genes of the PhoPR regulon. Mtb strain CDC1551 was grown at 37C in T-25 vented, standing tissue culture flasks in 8 ml of buffered 7H9 ...
ORGANISM(S): Mycobacterium tuberculosis 
2015-05-20 | E-GEOD-63917 | biostudies-arrayexpress
TranscriptomicsTranscriptome signature in early biopsies of stably functioning kidney allografts identify patients at risk for chronic injury
Chronic injury in kidney transplants remains a major cause of graft loss. The aim of this study was to identify a predictive gene set capable of classifying renal grafts at risk for progressive injury due to fibrosis.The Genomics of Chronic Allograft Rejection (GoCAR) study is a prospective, multice...
ORGANISM(S): Homo sapiens 
2016-07-20 | E-GEOD-57387 | biostudies-arrayexpress
UnknownIn vivo CRISPR screening in head and neck cancer reveals Uchl5 as an immunotherapy target.
Not available
S-EPMC12480505 | biostudies-literature
TranscriptomicsWhole Genome Sequencing Informs Therapeutic Selection for Pancreatic Cancer
Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole genome sequencing and CNV analysis of 100 pancreatic ductal adenocarcinomas. Chromosomal rearrangements leading to gene disruption were frequent, affecting genes known to be important in pa...
ORGANISM(S): Homo sapiens 
2015-02-27 | E-GEOD-61502 | biostudies-arrayexpress
UnknownCardiorespiratory Monitoring Data to Predict Respiratory Outcomes in Extremely Preterm Infants.
Not available
S-EPMC10870840 | biostudies-literature
UnknownTwo phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer's disease.
Not available
S-EPMC4159618 | biostudies-literature
TranscriptomicsICGC Pancreas: Genomic analysis reveals roles for chromatin modification and axonguidance in pancreatic cancer
Pancreatic cancer (PC) is the fourth leading cause of cancer death with an overall 5-year survival rate of < 5%, a statistic that has changed little in almost 50 years. A deeper understanding of the underlying molecular pathophysiology is expected to advance the urgent need to develop novel therapeu...
ORGANISM(S): Homo sapiens 
2012-03-30 | E-GEOD-36924 | biostudies-arrayexpress
GenomicsQCMG_20130826 - samples
Analysis .bam files from HiSeq sequencing of Australian ICGC PDAC study samples, submitted 20130826
EGAD00001000660 | EGA
GenomicsQCMG20130201_pancreatic - samples
Sequencing data for Australian Pancreatic Cancer study submitted 20130102
EGAD00001000323 | EGA
GenomicsRNASeq_PACA-AU_Apr_2017 - samples
BAM outputs from RSEM (https://deweylab.github.io/RSEM/) analysis of RNASeq sequencing on HiSeq platform of tumour samples from 95 pancreatic adenocarcinoma cases.
EGAD00001003298 | EGA
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