Background: The lifetime prevalence of acute urticaria is approximately 20%. Although electroacupuncture (EA) has been investigated as an adjunctive treatment for urticaria, the molecular mechanisms underlying these effects remain elusive. Passive cutaneous anaphylaxis (PCA) serves as an experime...
Ischemia–reperfusion injury (IRI) is a major cause of acute kidney injury and can lead to chronic kidney disease, with the complement system playing a key role, though the relative importance of early (C3) versus late (C5) components is unclear. In this study, IRI was induced in rats lacking C3 or C...
The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis. Dysregulation as a consequence of genetic or environmental cues can lead to inflammatory syndromes or increased susceptibility to infection. Howev...
Identification of transcriptional profiles stimulated by the complement protein C1q in rat immature neurons associated with the C1q-dependent neuroprotection observed in vitro. Use of the unbiased whole genome microarray approach to identify genes regulated by C1q. Immature neurons grown in vitro fo...
We identified a rare C5 gene variant in individuals with a history of Neisseria meningitis, suggesting a complement deficiency as a predisposing factor.
