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MetabolomicsElectroacupuncture at Ll11 and SP10 is associated with alleviation of acute urticaria-like reactions in passive cutaneous anaphylaxis: an exploratory analysis of complement-related proteins and multiscale omics

Background: The lifetime prevalence of acute urticaria is approximately 20%. Although electroacupuncture (EA) has been investigated as an adjunctive treatment for urticaria, the molecular mechanisms underlying these effects remain elusive. Passive cutaneous anaphylaxis (PCA) serves as an experime...

2026-06-03 | MTBLS14327 | MetaboLights
TranscriptomicsComplement Factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice.
Purpose: The complement system is closely linked to the pathogenesis of age-related macular degeneration (AMD). Several complement genes are expressed in retinal pigment epithelium (RPE), and complement proteins accumulate in drusen. Further, a common variant of complement factor H (CFH) confers inc...
ORGANISM(S): Mus musculus 
2012-10-02 | E-GEOD-38671 | biostudies-arrayexpress
ProteomicsUrine complement analysis implies complement activation is involved in membranous nephropathy
Total 1,427 differentially expressed proteins were identified between the MN and HC groups. KEGG pathway analysis showed significant enrichment of these DEPs in the complement-activated pathway within the MN group. Additionally, a correlation was found between proteinuria and the levels of 27 urinar...
ORGANISM(S): Homo Sapiens 
2025-02-01 | PXD060494 |
TranscriptomicsRegulation of neuronal gene and miRNA expression by the complement protein C1q associated with neuroprotection
Identification of transcriptional profiles stimulated by the complement protein C1q in rat immature neurons associated with the C1q-dependent neuroprotection observed in vitro. Use of the unbiased whole genome microarray approach to identify genes regulated by C1q. Immature neurons grown in vitro fo...
ORGANISM(S): Rattus norvegicus 
2011-03-07 | E-GEOD-18860 | biostudies-arrayexpress
TranscriptomicsThe alternative complement pathway appears to be a UVA sensor that leads to systemic immunosuppression
Ultraviolet (UV) wavebands in sunlight are immunomodulatory. About half the amount of UVA within a minimum erythemal dose of sunlight is systemically immunosuppressive, while higher doses protect from UVB immunosuppression in mice. We have previously shown that these responses to UVA are genetically...
ORGANISM(S): Mus musculus 
2010-05-16 | E-GEOD-15618 | biostudies-arrayexpress
TranscriptomicsRepeated systemic challenge with lipopolysaccharides induces dopaminergic neurodegeneration in the brain by activation of the complement-phagosome pathway
Systemic inflammatory reactions mediated by chronic infections activate microglia in the central nervous system (CNS) and have been postulated to exacerbate neurodegenerative diseases. We now demonstrate in vivo that repeated systemic challenge of mice with bacterial lipopolysaccharides (LPS) mainta...
ORGANISM(S): Mus musculus 
2014-07-11 | E-MTAB-1770 | biostudies-arrayexpress
ProteomicsTargeted MRM assay Complement System in Health and Infectious Disease
The complement system is a central component of the innate immune system. Constitutive biosynthesis of complement proteins is essential for homeostasis. Dysregulation as a consequence of genetic or environmental cues can lead to inflammatory syndromes or increased susceptibility to infection. Howev...
ORGANISM(S): Homo Sapiens 
2019-08-06 | PXD014264 | panorama
ProteomicsThioredoxin reduces complement factor H and alters its complement regulatory function
Complement factor H (CFH) is an enzyme responsible for inactivating components of the complement cascade, thus limiting the downstream effector mechanisms which would otherwise occur were the process to continue unregulated. In view of the close structural and functional homology between β2GPI and C...
ORGANISM(S): Homo sapiens (Human) 
2019-05-20 | PXD009558 | Pride
Complement factor h Thioredoxin Disulfide bonds 
TranscriptomicsRNAi knock down of endogenous genes and luciferase reporters in human HeLa cells to examine the effect of seed complement frequency on off-target signatures
siRNAs were designed against both endogenous genes and luciferase reporters to examine the effect of seed complement frequency on off-target signatures as measured by Agilent Human 1A gene expression analysis.
ORGANISM(S): Homo sapiens 
2008-03-15 | E-MEXP-1402 | biostudies-arrayexpress
TranscriptomicsEffect of Alloantibody and Complement on Endothelial Cells
Examine the possible pro-inflammatory gene effects of alloantibody and complement on endothelial cells Microarray 3 Experiment performed three times on three separate microarrays using three separate HUVEC and PRA donors. In each experiment, there are four groups of HUVEC with three replicates per g...
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-50112 | biostudies-arrayexpress
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