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ProteomicsThe interactome of Complexin 4-SNARE complexes in mouse retina
Complexin (Cplx)3 and Cplx4, SNARE-complex-regulators of the Cplx family, have been proposed to be involved in the light adaptation of ribbon synapses by limiting synaptic vesicle (SV) recruitment and fusion, but how this Cplx effect is exerted is unknown. Focusing on light adaptation of rod photore...
ORGANISM(S): Mus musculus (Mouse) 
2024-02-20 | PXD047206 | Pride
Mouse retina Ribbon synapses G protein Label-free quantification Complexin 4 Data-independent acquisition 
ProteomicsMass Spectrometry Uncovers Protein Interactions and Stoichiometry of Intermediates and Sub-complexes for SNARE Complex Assembly
The neuronal SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 anchored to the presynaptic membrane. It mediates fusion of synaptic vesicles with the presynaptic plasma membrane resulting in exocytosis of neurotransmitters into the synaptic cleft. While the gene...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-01-25 | PXD030619 | Pride
Native mass spectrometry Chemical cross-linking Snare complex Complexin-1 Signal transmission in neurons 
UnknownLight-dependent regulation of neurotransmitter release from rod photoreceptor ribbon synapses involves an interplay of Complexin 4 and Transducin with the SNARE complex.
Not available
S-EPMC10932955 | biostudies-literature
UnknownRe-visiting the trans insertion model for complexin clamping.
Not available
S-EPMC4384536 | biostudies-literature
UnknownComplexin-1 and synaptotagmin-1 compete for binding sites on membranes containing PtdInsP2.
Not available
S-EPMC9515229 | biostudies-literature
UnknownEvolutionary Divergence of the C-terminal Domain of Complexin Accounts for Functional Disparities between Vertebrate and Invertebrate Complexins.
Not available
S-EPMC5445133 | biostudies-literature
UnknownComplexin 2 modulates vesicle-associated membrane protein (VAMP) 2-regulated zymogen granule exocytosis in pancreatic acini.
Not available
S-EPMC2975180 | biostudies-literature
UnknownThe carboxy-terminal domain of complexin I stimulates liposome fusion.
Not available
S-EPMC2632952 | biostudies-literature
UnknownEnrichment and differential targeting of complexins 3 and 4 in ribbon-containing sensory neurons during zebrafish development.
Not available
S-EPMC2941751 | biostudies-literature
UnknownRetinoic Acid and LTP Recruit Postsynaptic AMPA Receptors Using Distinct SNARE-Dependent Mechanisms.
Not available
S-EPMC4578641 | biostudies-literature
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