Sort   by:  
 Page size 
TranscriptomicsIn vivo screen of Francisella tularensis subsp. novicida mutants in sequence defined transposon library
We used an inhalation mouse model of infection to query a collection of 2149 mutants in a Francisella tularensis subsp. novicida background for genes required for growth, survival and systemic dissemination. A microarray-based genome-wide negative selection screen (Microarray tracking of transposon ...
ORGANISM(S): Francisella tularensis subsp. novicida 
2008-12-30 | E-GEOD-11297 | biostudies-arrayexpress
GenomicsOxidosqualene cyclase targeting compound in Leishmania
Overexpression library screen - Oxidosqualene cyclase targeting compound in Leishmania donovani
PRJEB37256 | ENA
TranscriptomicsHigh throughput screening for chemical inducers of stumpy formation in Trypanosoma brucei
During the bloodstream stage of the Trypanosoma brucei lifecycle, the parasite exists as the proliferative slender-form or the non-proliferative, transmissible, stumpy-form. The transition from the slender to stumpy-form is stimulated by a density-dependent mechanism and is important in infection dy...
ORGANISM(S): Trypanosoma brucei brucei 
2014-01-21 | E-GEOD-46483 | biostudies-arrayexpress
GenomicsEpigenetic library screen reveals novel targets for uveal melanoma
Epigenetic library screen reveals novel targets for uveal melanoma
PRJNA1252089 | ENA
TranscriptomicsCompensatory IKKa activation of classical NF-kB signaling during IKKb inhibition
A subtype of diffuse large B-cell lymphoma (DLBCL), termed activated B-cell-like (ABC) DLBCL, depends on constitutive NF-kB pathway signaling for survival. Small molecule inhibitors of IkB kinase b (IKKb), a key regulator of the NF-kB pathway, kill ABC DLBCL cells and hold promise for the treatment ...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-11902 | biostudies-arrayexpress
TranscriptomicsEpigenetic library screen reveals novel targets for uveal melanoma
Uveal melanoma (UM) is the most common primary ocular cancer in adults, which metastasizes mainly to the liver in around half of the cases. The limited potency of current treatment options for metastatic UM necessitates an urgent exploration of novel therapeutic approaches to improve patient prognos...
ORGANISM(S): Homo sapiens 
2025-04-22 | GSE294950 | GEO
ProteomicsRobust proteome profiling of cysteine-reactive fragments using label-free chemoproteomics - 80 compound screen (HEK293T and Jurkat)
In this manuscript we describe our work on the development of a label-free chemoproteomics screening platform for cysteine reactive covalent fragments on a 96 well plate format. Within this workflow, we profile cysteine reactive fragments by competition with the hyper-reactive iodoacetamide desthiob...
ORGANISM(S): Homo sapiens (Human) 
2024-11-18 | PXD054127 | Pride
Chemoproteomics Data independant acquisition Label-free qauntification 
UnknownAccelerating antiviral drug discovery: early hazard detection with a dual zebrafish and cell culture screen of a 403 compound library.
Not available
S-EPMC11821682 | biostudies-literature
UnknownIdentification and Evaluation of Reversible Covalent Binders to Cys55 of Bfl-1 from a DNA-Encoded Chemical Library Screen.
Not available
S-EPMC11181504 | biostudies-literature
TranscriptomicsIdentification of new genes involved in human adipogenesis and fat storage
Since the worldwide increase in obesity represents a growing challenge for the health care systems, new approaches are needed to treat obesity and associated disease effectively. The food intake is primarily stored in the adipose tissue and therefore this organ is in focus to develop new anti-obesit...
ORGANISM(S): Homo sapiens 
2012-03-06 | E-GEOD-28628 | biostudies-arrayexpress
Sort   by:  
 Page size