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ProteomicsProximity labeling in Arabidopsis seedlings expressing R-degron-Turbo vs. M-degron-Turbo vs. L-degron-Turbo untreated (DMSO control), treated with 10µM Bortezomib and treated with 1µM Concanamycin A.
Goal was to identify N-recognins for Arginine and Leucine by comparison of biotinylated proteins from 1 week old whole Arabidopsis seedlings constitutively expressing the bait constructs R-degron-Turbo or L-degron-Turbo. M-degron-Turbo served as a negative control. The plants were treated with 50µM ...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-04-15 | PXD041610 | Pride
Bortezomib N-degron pathway Proximity labeling Concanamycin a Protein turnover Turbo 
GenomicsRNA sequencing of S. Cerevisiae treated with the Vacuolar H+-ATPase inhibitor concanamycin A (concA)
RNA sequencing of S. Cerevisiae treated with the Vacuolar H+-ATPase inhibitor concanamycin A (concA)
PRJNA550397 | ENA
UnknownConcanamycin A counteracts HIV-1 Nef to enhance immune clearance of infected primary cells by cytotoxic T lymphocytes.
Not available
S-EPMC7519347 | biostudies-literature
MetabolomicsDigital Phenomics and Dual-Fluid Metabolomics for Precision Stratification of Diabetic Kidney Disease: A Multicenter Cohort Study

We conducted a prospective-retrospective two-center cohort study involving 364 participants. The Discovery Cohort (n=282) enrolled from two centers consisted of healthy controls (n=80), patients with type 2 diabetes mellitus (T2DM) without kidney disease (n=102), and patients with confirmed DKD (...

2026-03-09 | MTBLS14007 | MetaboLights
UnknownOptimized production of concanamycins using a rational metabolic engineering strategy.
Not available
S-EPMC11908387 | biostudies-literature
TranscriptomicsCo-Culture of CD8+ T cells and Breast Cancer Cells
Targeting of tumor immune escape mechanisms holds enormous therapeutic potential. Still, most patients progress under immune checkpoint blockade and some even become hyper-progressors. To investigate how cancer cells respond to activated but ineffective T cells, we challenged peptide-loaded MCF-7 br...
ORGANISM(S): Homo sapiens 
2019-11-25 | GSE108236 | GEO
TranscriptomicsRNA sequencing of S. Cerevisiae treated with the Vacuolar H+-ATPase inhibitor concanamycin A (concA)
RNA sequencing results identifying transcript abundance changes that occur after treating budding yeast with V-ATPase inhibitors
ORGANISM(S): Saccharomyces cerevisiae 
2020-04-22 | GSE133214 | GEO
TranscriptomicsDMSO-induced human embryo model reveals V-ATPase requirement in cavitation
This study focuses on the key regulatory mechanisms of lysosomal acidification in early human embryonic development. By employing single-cell RNA sequencing technology (Smart-seq2), we conducted a systematic analysis of human morulae derived from three pronuclei, embryos arrested in development afte...
ORGANISM(S): Homo sapiens 
2026-03-12 | GSE291369 | GEO
UnknownConcanamycins Are Key Contributors to the Virulence of the Potato Common Scab Pathogen Streptomyces scabiei.
Not available
S-EPMC12648119 | biostudies-literature
UnknownDisruption of pH Dynamics Suppresses Proliferation and Potentiates Doxorubicin Cytotoxicity in Breast Cancer Cells.
Not available
S-EPMC7916175 | biostudies-literature
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