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ProteomicsProteomic profiling of eIF3a conditional knockout mice
In this study, a Cre-loxP system was used to generate eIF3a conditional knockout mice. Tandem mass tag (TMT) labeling with LC-MS/MS analysis was used to identify differentially expressed proteins (DEPs) in fat, lungs, skin, and spleen tissue of the eIF3a knockout mice and controls. Bioinformatics an...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD041416 | Pride
Eif3a Proteomics Knockout mice Protein landscape Oxidative stress 
TranscriptomicsRNA sequencing (RNA-SEQ) of Dnmt1 and Dnmt3a conditional knockout mice
Purpose: Epigenetic regulation contributes to pathogenesis of neurondegenerative disease. We found that dis-regulation of a 242-gene subnetwork related to DNA methylation regulated neuronal differentiation are common in AD and HD. There are two DNA methyltransferases, DNMT1 and DNMT3A, in the subn...
ORGANISM(S): Mus musculus 
2014-07-31 | E-GEOD-58261 | biostudies-arrayexpress
TranscriptomicsEffect of a cardiomyocyte-specific Hira conditional knockout on gene expression in the heart
We performed gene expression profiling by microarray using RNA extracted from healthy free wall left ventricle tissues from control and Hira cardiomyocyte-specific conditional knockout mice at 6 weeks of age. Hira is a histone chaperone responsible for replication-independent incorporation of histo...
ORGANISM(S): Mus musculus 
2016-04-06 | E-GEOD-71833 | biostudies-arrayexpress
TranscriptomicsComprehensive proteomic and transcriptomic characterization of hepatic expression signatures affected in p14 liver conditional knockout mice
Scaffold proteins regulate intracellular MAP kinase signaling by providing critical spatial and temporal specificity. We have shown previously that the scaffold protein MEK1 partner (MP1) is localized to late endosomes by the adaptor protein p14. Using conditional gene disruption of p14 in livers of...
ORGANISM(S): Mus musculus 
2011-02-01 | E-GEOD-24461 | biostudies-arrayexpress
TranscriptomicsTranscriptional Profiling of Neuronal APP/APLP2 Double-Conditional Knockout Mice.
Gene expression analysis of 2-month-old APP/APLP2 double-conditional Knockout (N-dCKO) mice and littermate APLP2 knockout controls, APP knockout and wildtype controls. Mouse hippocampus were dissected for RNA extraction and hybridization on Affymetrix microarrays.
ORGANISM(S): Mus musculus 
2013-07-10 | E-GEOD-48622 | biostudies-arrayexpress
TranscriptomicsDifferential miRNA expression caused by Dicer knockout in small intestine
Dicer knockout cause lipid metabolism dysregulation in small intestine. Analyses of transcriptomics and proteomics reveal key enzymes affected by Dicer knockout. Conditional knockout of Dicer in adult mice
ORGANISM(S): Mus musculus 
2012-01-07 | E-GEOD-34909 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression caused by Dicer knockout in small intestine
Dicer knockout cause lipid metabolism dysregulation in small intestine. Analyses of transcriptomics and proteomics reveal key enzymes affected by Dicer knockout. Conditional knockout of Dicer in adult mice
ORGANISM(S): Mus musculus 
2012-01-07 | E-GEOD-34905 | biostudies-arrayexpress
TranscriptomicsGene mRNA levels in the bone of FAM20C KO mice VS WT mice (3-WK-old)
Family with sequence similarity 20-member C (FAM20C) is a new molecule that is highly expressed in the mineralized tissues of mammals. Genetic studies showed that the loss-of-function mutations in FAM20C were associated with human lethal osteosclerotic bone dysplasia (Raine Syndrome), indicating tha...
ORGANISM(S): Mus musculus 
2012-02-17 | E-MTAB-772 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse presenilin conditional double knockout cerebral cortex at 6 months old
Gene expression profile of presenilin conditional double knockout cerebral cortex, comparing to control. Age of mice: 6 months
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-1375 | biostudies-arrayexpress
TranscriptomicsExpression data from mouse proximal intestinal epithelial Lgr5(hi) stem cells and differentiated villus cells (enterocytes from Atoh1 conditional knockout)
We used microarrays to detail the differentail gene expression between intestinal Lgr5(hi) stem cells and differentiated cells Assay the differential gene expression using total RNA from flow cytometry sorted Lgr5(hi) cells and EDTA isolated enterocytes from Atoh1 conditional knockout
ORGANISM(S): Mus musculus 
2012-10-13 | E-GEOD-41541 | biostudies-arrayexpress
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