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We report our synthetic and chemical proteomics studies of marine cyclopiane diterpenes which culminate in the asymmetric total synthesis of conidiogenones C, K and 12β-hydroxy conidiogenone C, and identification of Immunity-related GTPase family M protein 1 (IRGM1) as a cellular target using an alk...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD056084 | Pride
We proceeded to competitive chemoproteomic profiling with conidiogenone C probe in LPS-stimulated RAW264.7 cell lysates. The lysis was then reacted with azide-biotin, and after enrichment and digestion, the peptides were labeled as “light, “medium” or “heavy” by dimethyl labeling. The labeled prote...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD047981 | Pride
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