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MetabolomicsGlobal Metabonomic and Proteomic Analysis of Human Conjunctival Epithelial Cells (IOBA-NHC) in Response to Hyperosmotic Stress
“Dry eye” is a multi-factorial inflammatory disease affecting the ocular surface. Tear hyperosmolarity in dry eye contributes to inflammation and cell damage. Recent research efforts on dry eye have been directed towards biomarker discovery for diagnosis, response to treatment and disease mechanisms...
2015-08-31 | MTBLS214 | MetaboLights
TranscriptomicsTranscription profiling by array of human conjunctival epithelial side population cells
Side population (SP) cells isolated from limbal and conjunctival epithelia derive from cells that are slow cycling in vivo, a known feature of tissue stem cells. The purpose of this study was to define the molecular signature of the conjunctival side population cells by global differential gene expr...
ORGANISM(S): Homo sapiens 
2009-11-11 | E-GEOD-12631 | biostudies-arrayexpress
TranscriptomicsMouse conjunctival forniceal gene expression during postnatal development and its regulation by Kruppel-like factor 4
Purpose: To identify the changes in postnatal mouse conjunctival forniceal gene expression and their regulation by Klf4 around eye opening stage when the goblet cells first appear. Methods: Laser-capture-microdissection was used to collect conjunctival forniceal epithelial cells from postnatal-day (...
ORGANISM(S): Mus musculus 
2011-06-15 | E-GEOD-26076 | biostudies-arrayexpress
TranscriptomicsConjunctival miRNA expression data in scarring and inflammatory trachoma
Ocular infection with Chlamydia trachomatis (trachoma) is the leading cause of blindness that results from infection. Chronic inflammation is believed to drive the scarring process and the progressive blinding disease, however the mechanisms by which this occurs are not completely understood. We hyp...
ORGANISM(S): Homo sapiens 
2013-06-11 | E-GEOD-37717 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human post-mortem conjunctivae and corneal epithelia
Whole human conjunctivae and human corneas were obtained from the National Disease Research Interchange (NDRI, Philadelphia, PA) and processed between 48 - 72 hr of death. No donor details apart from age, sex and cause of death were released. Criteria for inclusion were donor ages between 25 - 65 ye...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-5543 | biostudies-arrayexpress
GenomicsThe Gene Profile of Senescent Conjunctival Cells
The Gene Profile of Senescent Conjunctival Cells
PRJNA993691 | ENA
GenomicsConjunctival epithelial cells resist productive SARS-CoV-2 infection
Conjunctival epithelial cells resist productive SARS-CoV-2 infection
PRJNA790648 | ENA
GenomicsStrain differences in conjunctival gene expression profiles
Strain differences in conjunctival gene expression profiles
PRJNA909191 | ENA
TranscriptomicsTranscription profiling time series of a human conjunctival epithelial cell line treated with retinoic acid
Purpose. How vitamin A contributes to the maintenance of the wet-surfaced phenotype at the ocular surface is not well understood. We sought to identify vitamin A responsive genes in ocular surface epithelia using gene microarray analysis of cultures of a human conjunctival epithelial cell line (HCjE...
ORGANISM(S): Homo sapiens 
2007-12-12 | E-GEOD-2835 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human conjunctival epithelial cell lines
Human conjunctival cell lines are useful tools for modeling ocular surface disease and evaluation of ocular drugs. Here we demonstrate that the IOBA-NHC and the ChWK conjunctival epithelial cell lines show, using an unbiased gene microarray approach, unique gene expression signatures that differ fro...
ORGANISM(S): Homo sapiens 
2008-06-16 | E-GEOD-8633 | biostudies-arrayexpress
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