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TranscriptomicsMolecular mechanisms of hepatocarcinogenesis in c-Myc/Tgfa transgenic mice
A complete understanding of molecular mechanisms that underlie cancer onset and progression could provide a basis to improve early diagnosis and more effective treatment. However, this is still a challenge in human, partly due to the difficulty of analyzing the early stages of the disease. In this c...
ORGANISM(S): Mus musculus 
2011-09-27 | E-GEOD-25587 | biostudies-arrayexpress
TranscriptomicsDifferentiation stage-specific donor memory in induced pluripotent stem cells (iPSC) generated from hepatic lineage cells
Recent studies suggested that embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) may represent different pluripotent states as defined by gene expression profiles and differentiation potential. Here we addressed a contribution of a lineage stage-specific donor cell memory in mod...
ORGANISM(S): Mus musculus 
2012-10-02 | E-GEOD-33110 | biostudies-arrayexpress
TranscriptomicsDEN-induced HCC in c-Met knockout mice
HGF has been reported to have both positive and negative effects on carcinogenesis. Here we show that the loss of c-Met signaling in hepatocytes enhanced rather than suppressed the early stages of chemical hepatocarcinogenesis. c-Met conditional knockout mice (c-metfl/fl, AlbCre+/-; MetLivKO) treate...
ORGANISM(S): Mus musculus 
2008-08-09 | E-GEOD-8747 | biostudies-arrayexpress
TranscriptomicsmTOR inhibitors synergistically induce regression, reversal of gene expression and autophagy in hepatocellular carcinoma
The mTOR-allosteric inhibitor, RAD001, in combination with a PI3K/mTOR ATP-site competitive inhibitor, BEZ235, causes gene reprogramming, autophagy and tumor regression, in a mouse model approximating human HCC with poor prognosis, leading to an investigator Phase 1B-2 clinical trial. Comparative st...
ORGANISM(S): Mus musculus 
2012-07-11 | E-GEOD-37129 | biostudies-arrayexpress
TranscriptomicsProfiling of hepatic progenitor cells isolated from Egfr fl/fl and Met fl/fl murine control livers
Transcriptomic profiling; Determination of the transcriptomic similarity between Egfr fl/fl and Met fl/fl progenitor cells isolated from excised livers (n=3, each) Profiling of hepatic progenitor cells
ORGANISM(S): Mus musculus 
2013-09-05 | E-GEOD-46981 | biostudies-arrayexpress
UnknownA novel phenotype in N-glycosylation disorders: Gillessen-Kaesbach-Nishimura skeletal dysplasia due to pathogenic variants in ALG9.
Not available
S-EPMC4717212 | biostudies-literature
UnknownA pilot study of pNGVL4a-CRT/E7(detox) for the treatment of patients with HPV16+ cervical intraepithelial neoplasia 2/3 (CIN2/3).
Not available
S-EPMC4724445 | biostudies-literature
UnknownVaccination with mycobacterial lipid loaded nanoparticle leads to lipid antigen persistence and memory differentiation of antigen-specific T cells.
Not available
S-EPMC10028924 | biostudies-literature
UnknownA Knock-In Mouse Model of Thymoma With the GTF2I L424H Mutation.
Not available
S-EPMC9691559 | biostudies-literature
UnknownBaseline Features and Reasons for Nonparticipation in the Colonoscopy Versus Fecal Immunochemical Test in Reducing Mortality From Colorectal Cancer (CONFIRM) Study, a Colorectal Cancer Screening Trial.
Not available
S-EPMC10336619 | biostudies-literature
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