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ProteomicsHIV-1 Nef Reprograms Neuronal Lipid Rafts to Drive Neuroinflammation and Neurodegeneration in HIV-associated Neurocognitive Impairment
HIV-associated neurological disorders (HAND) remain a common co-morbidity of HIV infection. HIV protein Nef has been shown to increase the abundance of neuronal lipid rafts - cholesterol- and sphingolipid-rich membrane microdomains implicated in neurodegeneration and neuroinflammation. Here, we inve...
ORGANISM(S): Homo sapiens (Human) 
2026-03-23 | PXD065713 | Pride
Nef Exosomes. Neurons Hiv Hiv-associated neurological disorder Lipid rafts Neurodegeneration 
TranscriptomicsImmune regulation by low doses of the DNA methyltransferase inhibitor 5-azacitidine in common human epithelial cancers [methylation]
Epigenetic therapy is emerging as a potential therapy for solid tumors. To investigate its mechanism of action, we performed integrative expression and methylation analysis of 63 cancer cell lines (breast, colorectal, and ovarian) after treatment with the DNA methyltransferase inhibitor 5-azacitidin...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-57342 | biostudies-arrayexpress
TranscriptomicsEffect of AZA on gene expression of multiple breast, colon, and ovarian cell lines [expression]
Epigenetic therapy is emerging as a potential therapy for solid tumors. To investigate its mechanism of action, we performed integrative expression and methylation analysis of 63 cancer cell lines (breast, colorectal, and ovarian) after treatment with the DNA methyltransferase inhibitor 5-azacitidin...
ORGANISM(S): Homo sapiens 
2014-05-08 | E-GEOD-57341 | biostudies-arrayexpress
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Not available
S-EPMC8598213 | biostudies-literature
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Not available
S-EPMC8121538 | biostudies-literature
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