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UnknownMutational Spectrum, Copy Number Changes, and Outcome: Results of a Sequencing Study of Patients With Newly Diagnosed Myeloma.
Not available
S-EPMC6485456 | biostudies-literature
MetabolomicsSurvival, gene and metabolite responses of Litoria verreauxii alpina frogs to fungal disease chytridiomycosis
The fungal skin disease chytridiomycosis has caused the devastating decline and extinction of hundreds of amphibian species globally, yet the potential for evolving resistance, and the underlying pathophysiological mechanisms remain poorly understood. We exposed 406 naïve, captive-raised alpine tree...
2018-01-09 | MTBLS457 | MetaboLights
ProteomicsHuman serum from patients at multiple time points after ischemic stroke
Application of acute therapies such as thrombolysis for ischemic stroke (IS) is constrained because of diagnostic uncertainty and the dynamic nature of stroke biology. To investigate changes in blood proteins after stroke and as a result of thrombolysis treatment we performed label-free quantitativ...
ORGANISM(S): Homo sapiens (Human) 
2018-10-25 | PXD003218 | Pride
Human Ischemic stroke Serum 
ProteomicsTIA1 interactome from mouse cortex
The purpose of this experiment was to characterize the network of proteins that interact with TIA1, and to investigate whether tau exerts control over TIA1 protein interactions, TIA1 was immunoprecipitated from cortical brain tissue of 10 month-old WT (C57BL/6J), tau-/- and TIA1-/- mice. The specifi...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-26 | PXD003922 | Pride
Stress granule Map Translational regulation Alzheimer's disease Rna binding protein Rna metabolism Stress 
TranscriptomicsExpression analysis of superior cervical ganglion from backcrossed TH-MYCN transgenic mice
Neuroblastoma susceptibility in TH-MYN mice is heavily influence by mouse strain background. We have combined linkage analysis of tumor susceptibility with expression QTL analysis of superior cervical ganglia (pure peripheral symptathetic nervous tissue) to identify genes underlying tumor formation...
ORGANISM(S): Mus musculus 
2015-01-30 | E-GEOD-59675 | biostudies-arrayexpress
GenomicsClonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients
The emergence of treatment resistant sub-clones is a key feature of relapse in multiple myeloma. Therapeutic attempts to extend remission and prevent relapse include the maximisation of response and use of maintenance therapy. We used whole exome sequencing to study the genetics of paired presentati...
EGAS00001003539 | EGA
Genomicsena-DATASET-ICR-GM-05-05-2015-22:13:47:053-131 - samples
463 newly diagnosed patients from the UK Myeloma XI clinical trial (NCT01554852) underwent whole exome sequencing plus targeted capture of the IGH/K/L and MYC loci. 200 ng of DNA were processed using NEBNext DNA library prepartion kit and hybridised to the SureSelect Human All Exon V5 Plus. Four s...
EGAD00001001358 | EGA
Genomics463 newly diagnosed patients with Multiple Myeloma underwent whole exome sequencing of tumour and peripheral blood DNA.
463 newly diagnosed patients from the UK Myeloma XI clinical trial (NCT01554852) underwent whole exome sequencing plus targeted capture of the IGH/K/L and MYC loci. 200 ng of DNA were processed using NEBNext DNA library prepartion kit and hybridised to the SureSelect Human All Exon V5 Plus. Four s...
EGAS00001001147 | EGA
UnknownA draft genome sequence of the elusive giant squid, Architeuthis dux.
Not available
S-EPMC6962438 | biostudies-literature
UnknownCopy number evolution and its relationship with patient outcome-an analysis of 178 matched presentation-relapse tumor pairs from the Myeloma XI trial.
Not available
S-EPMC8257500 | biostudies-literature
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