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This study provides comprehensive proteomic profiles from the venom producing posterior salivary glands of Octopus (superorder Octopodiformes) species. A combined transcriptomic and proteomic approach was used to identify 1,703 proteins from the posterior salivary gland of the southern blue ring oct...
ORGANISM(S): Octopodiformes 
2022-02-28 | PXD003897 | Pride
Platelet hyperactivity contributes to increased cardiovascular thrombosis in diabetes. Intracellular and released proteins control platelet activity however there are limited proteomic studies of the diabetic platelet. We isolated platelets from 34 patients without, and 42 patients with type 2 diabe...
ORGANISM(S): Homo sapiens (Human) 
2025-04-19 | PXD049321 | Pride
Salmonella enterica serovar Typhimurium (S. Typhimurium) definitive phage type 104 (DT104) has caused significant morbidity and mortality in humans and animals for almost three decades. We have completed the full DNA sequence of one DT104 strain, NCTC13348 and show that the main differences between ...
ORGANISM(S): Salmonella enterica 
Cancer evolves dynamically, as clonal expansions supersede or overlap one another, driven by shifting selective pressures, mutational processes and disrupted cancer genes. These processes mark the genome, such that a cancerÕs life history is encrypted in the timing, ploidy, clonality and patterns of...
ORGANISM(S): Homo sapiens 
Tankyrases (TNKS) play roles in Wnt signaling, telomere homeostasis and mitosis, offering attractive targets for anti-cancer treatment. Using unbiased combination screening in a large panel of cancer cell lines, we have identified a strong synergy between TNKS and MEK inhibitors in KRAS mutant cance...
ORGANISM(S): Homo sapiens 
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