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ProteomicsiTRAQ Analysis of DJ-1 Knockout Rodent Brains
Mutations in the DJ-1 (Park7) gene cause autosomal recessive Parkinson's disease in humans, but the function of the DJ-1 protein is poorly characterized. In an effort to understand more about the biology of DJ-1, we performed iTRAQ analyses on subcellular fractions enriched from DJ-1 knockout rat an...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2017-10-04 | PXD005215 | Pride
Cytosol Itraq Dj-1 Mitochondria Hexokinase Parkinson's Neurodegeneration Subcellular fractionation Aging 
ProteomicsProteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice
Mutations in leucine-rich repeat kinase 2 (LRRK2) segregate with familial Parkinson’s disease (PD) and genetic variation in LRRK2 contributes to risk of sporadic disease. Although knockout of LRRK2 or knock-in of pathogenic mutations into the mouse germline does not result in a PD phenotype, several...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-01 | PXD008531 | Pride
Membrane trafficking Proteomics Lrrk2 Protein translation Lysosomal function Genetic mouse models Parkinson’s disease 
GenomicsIntegrated epigenome profiling of repressive histone modifications, DNA methylation and gene expression in normal and malignant urothelial cells [ChIP-Seq data]
We profiled two repressive histone modifications (H3K9m3 and H3K27m3) using ChIP-Seq in normal urothelial cells and cell lines representing non-invasive and invasive tumors. Two bladder cancer cell lines (RT112 and EJ/T24 from ATCC) and normal human urothelial (NHU) cells were treated according to s...
ORGANISM(S): Homo sapiens 
2011-08-03 | E-GEOD-31125 | biostudies-arrayexpress
TranscriptomicsTemporal dependency of the transcriptional response to carbohydrate depletion contrasts with conservation of the rapid response to sucrose readdition
To investigate whether the transcriptional response to carbon (C) depletion and sucrose re-addition depend on the duration of C-depletion, Arabidopsis thaliana seedlings growing in liquid culture in weak continuous light were harvested 3, 6, 12, 24, 48 and 72 h after removing sucrose from the medium...
ORGANISM(S): Arabidopsis thaliana 
2015-10-12 | E-MTAB-3143 | biostudies-arrayexpress
GenomicsGabriel Consortium Data Access Committee
Access to summary data and individual-level genotype data is available by submitting a free form application to the Gabriel Consortium DAC. Access to data will be granted to qualified investigators for appropriate use.
EGAC00000000014 | EGA
TranscriptomicsAbundant Quantitative Trait Loci for CpG Methylation and Expression Across Human Brain Tissues
A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human tissues. We describe a set of integrated experiments designed to investigate the effects of common genetic variability on DNA methylation, mRNA...
ORGANISM(S): Homo sapiens 
2010-04-20 | E-GEOD-15745 | biostudies-arrayexpress
TranscriptomicsMRCA expression
We have created a global map of the effects of polymorphism on gene expression in 400 children from families recruited through a proband with asthma. We genotyped 408,273 SNPs and identified expression quantitative trait loci from measurements of 54,675 transcripts representing 20,599 genes in Epste...
ORGANISM(S): Homo sapiens 
2013-01-09 | E-MTAB-1425 | biostudies-arrayexpress
GenomicsMRCA and MRCE SNP genotypes
Gene expression levels can be an important link DNA between variation and phenotypic manifestations. Our previous map of global gene expression based on approximately 400K SNPs and 50K transcripts in 400 sib pairs from the MRCA family panel has been widely used to interpret the results of GWAS. Here...
EGAS00000000137 | EGA
TranscriptomicsNorth American Brain Expression Consortium: DNA Methylation
A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human tissues. We describe a set of integrated experiments designed to investigate the effects of common genetic variability on DNA methylation and m...
ORGANISM(S): Homo sapiens 
2012-05-08 | E-GEOD-36194 | biostudies-arrayexpress
TranscriptomicsGenetic variants regulating ORMDL3 expression are determinants of susceptibility to childhood asthma
Asthma is caused by a combination of poorly understood genetic and environmental factors. We found multiple markers on chromosome 17q21 to be strongly and reproducibly associated with childhood onset asthma in family and case-referent panels with a combined P < 10-12. In independent replication stu...
ORGANISM(S): Homo sapiens 
2007-11-09 | E-GEOD-8052 | biostudies-arrayexpress
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