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ProteomicsiTRAQ Analysis of DJ-1 Knockout Rodent Brains
Mutations in the DJ-1 (Park7) gene cause autosomal recessive Parkinson's disease in humans, but the function of the DJ-1 protein is poorly characterized. In an effort to understand more about the biology of DJ-1, we performed iTRAQ analyses on subcellular fractions enriched from DJ-1 knockout rat an...
ORGANISM(S): Mus musculus (Mouse) Rattus norvegicus (Rat) 
2017-10-04 | PXD005215 | Pride
Cytosol Itraq Dj-1 Mitochondria Hexokinase Parkinson's Neurodegeneration Subcellular fractionation Aging 
ProteomicsProteomic analysis reveals co-ordinated alterations in protein synthesis and degradation pathways in LRRK2 knockout mice
Mutations in leucine-rich repeat kinase 2 (LRRK2) segregate with familial Parkinson’s disease (PD) and genetic variation in LRRK2 contributes to risk of sporadic disease. Although knockout of LRRK2 or knock-in of pathogenic mutations into the mouse germline does not result in a PD phenotype, several...
ORGANISM(S): Mus musculus (Mouse) 
2022-03-01 | PXD008531 | Pride
Membrane trafficking Proteomics Lrrk2 Protein translation Lysosomal function Genetic mouse models Parkinson’s disease 
TranscriptomicsAbundant Quantitative Trait Loci for CpG Methylation and Expression Across Human Brain Tissues
A fundamental challenge in the post-genome era is to understand and annotate the consequences of genetic variation, particularly within the context of human tissues. We describe a set of integrated experiments designed to investigate the effects of common genetic variability on DNA methylation, mRNA...
ORGANISM(S): Homo sapiens 
2010-04-20 | E-GEOD-15745 | biostudies-arrayexpress
Genomicsena-DATASET-UKBEC-30-11-2016-15:16:48:139-418 - samples
UKBEC 1st release of Exome data for 65 neuropathologically confirmed control individuals of European descent.
EGAD00001003100 | EGA
GenomicsExome sequencing of United Kingdom Brain Expression Consortium samples
The United Kingdom Brain Expression Consortium studies regulation of gene expression through common and rare variation. One of the main set of samples is compound by bulk brain tissue from 10 brain regions obtained from 134 controls.
EGAS00001002113 | EGA
GenomicsNINDS-Genome-Wide Genotyping in Parkinson's Disease: First Stage Analysis and Public Release of Data

Epidemiological studies have estimated a cumulative prevalence of PD of greater than 1 per thousand. When prevalence is limited to senior populations, this proportion increases nearly 10-fold. The estimated genetic risk ratio for PD is approximately 1.7 (70% increased risk for PD if a sibling...

phs000089.v3.p2 | EGA
UnknownLAG3 is not expressed in human and murine neurons and does not modulate ?-synucleinopathies
Not available
S-SCDT-EMM-2021-14745 | biostudies-other
UnknownGenetic influences on schizophrenia and subcortical brain volumes: large-scale proof of concept.
Not available
S-EPMC4852730 | biostudies-literature
UnknownExcessive burden of lysosomal storage disorder gene variants in Parkinson's disease.
Not available
S-EPMC5841393 | biostudies-literature
UnknownNovel genetic loci underlying human intracranial volume identified through genome-wide association.
Not available
S-EPMC5227112 | biostudies-literature
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