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TranscriptomicsValvular heart disease and atrial fibrillation regulate microRNA expression profiles in left and right atria differently
Background: Chronic atrial fibrillation (AF) is a complication associated with the dilated atria of patients with valvular heart disease and contributes to worsened pathology. Methods and Results: Using microarray technology, we examined microRNA (miR) expression profiles in right and left atrial ap...
ORGANISM(S): Homo sapiens 
2011-12-21 | E-GEOD-28954 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse finally differentiated 3T3-L1 adipocytes treated with insulin (0 or 100nM)or metformin (0 or 2mM)for 2 and 12 hours
Finally differentiated 3T3-L1 adipocytes are treated with insulin (0 or 100nM)or metformin (0 or 2mM)for 2 and 12 hours to understand insulin and metformin(an anti-diabetic drug commonly applied for Non-Insulin Dependent Diabetes Mellitus)action in adipose tissues.
ORGANISM(S): Mus musculus 
2013-01-30 | E-BAIR-8 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse H-2Kb muscle cells treated with metformin (2mM) or insulin (100nM) for 0, 2 or 12 hours
The basic design of the experiment is as described in Fryer et al.(2000)Diabetes 49:1978, and is similar to proto-BAIR (EXP_BAIR_0603_02). H-2Kb muscle cells were treated with metformin (2mM) or insulin (100nM) for 0, 2 or 12 hours.
ORGANISM(S): Mus musculus 
2022-11-23 | E-BAIR-7 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of peritoneal fat of SHR/01a (spontaneously hypertensive rat), BN-Lx (Brown Norway congenic carrying polydactyly-luxate syndrome)and recombinant inbred (HXB/BXH) 6-week old rat strains
Gene expression profiling of peritoneal fat of SHR/01a (spontaneously hypertensive rat), BN-Lx (Brown Norway congenic carrying polydactyly-luxate syndrome)and recombinant inbred (HXB/BXH) 6-week old rat strains.
ORGANISM(S): Rattus norvegicus 
2010-11-18 | E-AFMX-7 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of kidney from rats of SHR/Ola, BN and SHR-18 strains after being provided with drinking water with 1% or 0% sodium chloride
Four male SHR/Ola, BN and SHR-18 rats were fed a normal diet and sacrificed at 9 weeks of age. Four male SHR/Ola and SHR-18 rats at 8 weeks of age were fed 1% NaCl for one week and then sacrificed. Kidneys were removed and frozen in liquid nitrogen for all 20 animals. Total RNA was isolated, labelle...
ORGANISM(S): Rattus norvegicus 
2008-04-01 | E-MIMR-1122 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of ovarian gene expression in RIP140 wild type, heterozygous and knock out mice
Title: Comparison of ovarian gene expression in RIP140 wild type, heterozygous and knock out mice.
Description: RIP140 null mice fail to ovulate. This experiment was designed to
determine the gene expression profile of these animals compared
to wild type and heterozygous an...
ORGANISM(S): Mus musculus 
2005-05-11 | E-MIMR-43 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cells induced to express the HOXB1 transcription factor under doxycycline tet-on control
Undifferentiated mouse embryonic stem cells stably expressing the HOXB1 transcription factor under doxycycline tet-on control were differentiated into embryoid bodies. Nestin+ neuroepithelial cells were selected by transfer of the embryoid bodies to ISTFn media. Expression of HOXB1 was induced by ad...
ORGANISM(S): Mus musculus 
2008-06-30 | E-MIMR-441 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human CD4CD45RO T-cells stimulated with interleukin-2, interleukin-6 or TNF-alpha and harvested at 24, 72 or 144 hours or stimulated with anti-CD3 antibodies and harvested at 24 hours
Blood taken from a healthy human donor was used to isolate CD4CD45RO T-cells. Purified cells were stimulated with either interleukin-2 (IL-2), Interleukin-6 (IL-6) and TNF-alpha and harvested at 24 hours, 72 hours (3 days) and 144 hours (6 days) or anti-CD3 antibodies and harvested at 24 hours. Thes...
ORGANISM(S): Homo sapiens 
2008-06-01 | E-MIMR-341 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 5 human parental cell lines and 3 drug resistant variants by culturing the former continuously in the presence of cytotoxic drug doxorubicin
Title: Analysis of gene expression changes involved in the development of acquired drug resistance.
Description: In vitro model of drug resistance consisting of 5 parental cell lines and 3 drug resistant variants by culturing the former continuously in the presence of cytotoxic drug doxorubic...
ORGANISM(S): Homo sapiens 
2006-09-01 | E-MIMR-11 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of skeletal muscle tissue from wild type and RIP140-null mice fed a normal or high-fat diet
Mice which lack transcriptional corepressor RIP140 show muscle fibre-type switching and increased metabolic gene expression. Comparison between skeletal muscle tissue from wild type and RIP140-null mice fed normal or high-fat diet. Switched the diet when mice were 1 month old, then sampled at 3 mon...
ORGANISM(S): Mus musculus 
2022-11-23 | E-BAIR-13 | biostudies-arrayexpress
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