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TranscriptomicsRNA-sequencing of the GSI treatment of the CUTLL1 cell line
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring genetic defect, identified in more than 50% of T...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-61999 | biostudies-arrayexpress
TranscriptomicsRNA-sequencing of CD34+ thymocytes that were cultured on an OP9-GFP or OP9-DLL1 feeder layer.
Genetic studies in T-cell acute lymphoblastic leukemia have uncovered a remarkable complexity of oncogenic and loss-of-function mutations. Amongst this plethora of genetic changes, NOTCH1 activating mutations stand out as the most frequently occurring genetic defect, identified in more than 50% of T...
ORGANISM(S): Homo sapiens 
2014-10-27 | E-GEOD-62000 | biostudies-arrayexpress
Genomicsena-DATASET-VIB-CME-16-05-2014-16:10:17:695-121 - samples
Description not provided
EGAD00001000849 | EGA
GenomicsIdentification of point mutations, expression perturbations, and gene fusions in T-cell acute lymphoblastic leukemia by RNA-seq
RNA-seq is a promising technology to re-sequence protein-coding genes for the identification of single nucleotide variants, while simultaneously obtaining information on structural variations and gene expression perturbations. T-cell acute lymphoblastic leukemia (T-ALL) is caused by a combination of...
EGAS00001000536 | EGA
GenomicsVIB Institutional DAC
Data Access Committee EGAC00001002939
EGAC00001002939 | EGA
TranscriptomicsGene expression signatures of 64 T-ALL patient diagnosis samples
Genetic studies have shown that human T-ALLs can be divided into subgroups that are characterized by unique gene expression signatures and relate to stages of T-cell differentiation at which the leukemic cells arrest. Each molecular subgroup has characteristic genetic abnormalities that cause aberra...
ORGANISM(S): Homo sapiens 
2014-10-14 | E-GEOD-62156 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for RUNX1 knockdown in the ALL-SIL cell line.
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-62140 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for ETS1 knockdown in the ALL-SIL cell line.
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-62135 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for JQ1 treatment of the ALL-SIL cell line.
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-62139 | biostudies-arrayexpress
TranscriptomicsDevelopment of gene expression signatures for TLX1 knockdown in the ALL-SIL cell line.
The T-cell leukemia homeobox 1 (TLX1, HOX11) transcription factor is critically involved in the multistep pathogenesis of T-cell acute lymphoblastic leukemia (T-ALL) and often cooperates with NOTCH1 activation during malignant T-cell transformation. However, the exact molecular mechanisms by which t...
ORGANISM(S): Homo sapiens 
2015-08-05 | E-GEOD-62141 | biostudies-arrayexpress
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