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TranscriptomicsTRANSCRIPTIONAL REMODELLING IN RESPONSE TO CHANGING COPPER LEVELS IN WILSON DISEASE MODEL OF SACCHAROMYCES CEREVISIAE
A 3 x 2 factorial design was used to elucidate the genome-wide transcriptional response to the deletion of yeast ortholog of Wilson and Menkes disease causing gene; CCC2, at changing copper levels. Homozygous deletion mutant of CCC2, which encodes Cu+2 transporting P-type ATPase required to export c...
ORGANISM(S): Saccharomyces cerevisiae 
2013-09-02 | E-MEXP-3927 | biostudies-arrayexpress
ProteomicsCopper detoxification machinery of the brain-eating amoeba Naegleria fowleri involves copper-translocating ATPase and the antioxidant system
Copper is a trace metal that is necessary for all organisms but toxic when present in excess. Different mechanisms to avoid copper toxicity have been reported to date in pathogenic organisms such as Cryptococcus neoformans and Candida albicans. However, little if anything is known about pathogenic p...
ORGANISM(S): Naegleria fowleri 
2021-05-19 | PXD018807 | Pride
Hemerythrin Ionophores Naegleria fowleri Copper Oxidative stress Copper transporting atpase 
TranscriptomicsTranscription profiling of mouse model of Wilson disease reveals specific changes of liver transcriptome in the early stages of copper accumulation
Wilson disease (WD) is a severe metabolic disorder caused by genetic inactivation of copper-transporting ATPase ATP7B. In WD, copper accumulates in several tissues, particularly in the liver, inducing marked time-dependent pathological changes. To identify initial events in the copper-dependent de...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5348 | biostudies-arrayexpress
UnknownCopper Transporter ATP7A (Copper-Transporting P-Type ATPase/Menkes ATPase) Limits Vascular Inflammation and Aortic Aneurysm Development: Role of MicroRNA-125b.
Not available
S-EPMC6857803 | biostudies-literature
UnknownThe lumenal loop Met672-Pro707 of copper-transporting ATPase ATP7A binds metals and facilitates copper release from the intramembrane sites.
Not available
S-EPMC3143623 | biostudies-literature
UnknownCtpB is a plasma membrane copper (I) transporting P-type ATPase of Mycobacterium tuberculosis.
Not available
S-EPMC7017476 | biostudies-literature
UnknownSilencing of the Menkes copper-transporting ATPase (Atp7a) gene increases cyclin D1 protein expression and impairs proliferation of rat intestinal epithelial (IEC-6) cells.
Not available
S-EPMC4344117 | biostudies-literature
UnknownDiverse roles of the metal binding domains and transport mechanism of copper transporting P-type ATPases.
Not available
S-EPMC10973460 | biostudies-literature
UnknownPlumbagin Triggers Cuproptosis in Hepatocellular Carcinoma (HCC) via the DNA-Methyltransferase 1 (DNMT1)/microRNA-302a-3p (miR-302a-3p)/ATPase Copper Transporting Beta (ATP7B) Axis.
Not available
S-EPMC12318818 | biostudies-literature
UnknownSilencing the Menkes copper-transporting ATPase (Atp7a) gene in rat intestinal epithelial (IEC-6) cells increases iron flux via transcriptional induction of ferroportin 1 (Fpn1).
Not available
S-EPMC3861793 | biostudies-literature
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