Sort   by:  
 Page size 
TranscriptomicsGene Copy Number Aberrations are Associated with Survival in Histological Subgroups of Non-Small Cell Lung Cancer (copy number data)
Hypothesis: Non-small cell lung cancer (NSCLC) is characterized by a multitude of genetic aberrations with unknown clinical impact. In this study, we aimed to identify gene copy number changes that correlate with clinical outcome in NSCLC. To maximize the chance to identify clinically relevant event...
ORGANISM(S): Homo sapiens 
2011-11-01 | E-GEOD-28572 | biostudies-arrayexpress
TranscriptomicsValidation and copy number variation in inbred and wild mice
This SuperSeries is composed of the following subset Series: GSE24424: Copy number variation in inbred and wild mice GSE24640: Validation of a subset of copy number variants from GSE24424 by aCGH Refer to individual Series
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-24643 | biostudies-arrayexpress
TranscriptomicsMouse Segmental Duplication and Copy-Number Variation
Detailed analyses of the clone-based genome assembly reveal that the recent duplication content of mouse (4.94%) is now comparable to that of human (5.5%), in contrast to previous estimates from the whole-genome shotgun sequence assembly. The architecture of mouse and human genomes differ dramatical...
ORGANISM(S): Mus musculus 
2008-05-10 | E-GEOD-11369 | biostudies-arrayexpress
TranscriptomicsCopy number variation in the bovine genome
Copy number variations (CNVs), which represent a significant source of genetic diversity in mammals, are currently being associated with phenotypes of clinical relevance, mostly in humans and mice. Notwithstanding, little is known about the extent of CNV that contributes to genetic variation in catt...
ORGANISM(S): Bos taurus 
2010-04-22 | E-GEOD-18174 | biostudies-arrayexpress
TranscriptomicsCopy number variation in the genomes of twelve natural isolates of Caenorhabditis elegans
Background: Copy number variation is an important component of genetic variation in higher eukaryotes. The extent of natural copy number variation in C. elegans is unknown outside of 2 highly divergent wild isolates and the canonical N2 Bristol strain. Results: We have used array comparative genomic...
ORGANISM(S): Caenorhabditis elegans 
2010-05-17 | E-GEOD-19440 | biostudies-arrayexpress
TranscriptomicsMapping of copy-number alterations with massively parallel sequencing
This SuperSeries is composed of the following subset Series: GSE12019: Fine-scale mapping of copy-number alterations with massively parallel sequencing GSE13372: High-resolution mapping of copy-number alterations with massively parallel sequencing Refer to individual Series
ORGANISM(S): Homo sapiens 
2008-11-13 | E-GEOD-13373 | biostudies-arrayexpress
TranscriptomicsDNA copy-number changes
Gene amplifications and deletions frequently contribute to tumorigenesis. Characterization of these DNA copy-number changes is important for both the basic understanding of cancer and its diagnosis. Comparative genomic hybridization (CGH) was developed to survey DNA copy-number variations across a w...
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-49 | biostudies-arrayexpress
TranscriptomicsLandscape of somatic allelic imbalances and copy number alterations in human lung carcinoma
Lung cancer is the worldwide leading cause of death from cancer. This GEO series correspond to one of the BAC aCGH data sets used as validation cohort for the study: Landscape of somatic allelic imbalances and copy number alterations in human lung cancer, Int J Cancer 2012. Genomic profiling of 78 l...
ORGANISM(S): Homo sapiens 
2012-10-09 | E-GEOD-29065 | biostudies-arrayexpress
TranscriptomicsNormalization of Illumina Infinium whole-genome SNP data improves copy number estimates and allelic intensity ratios
Illumina Infinium whole genome genotyping (WGG) arrays are increasingly being applied in cancer genomics to study gene copy number alterations and allele-specific aberrations such as loss-of-heterozygosity (LOH). Methods developed for normalization of WGG arrays have mostly focused on diploid, norma...
ORGANISM(S): Homo sapiens 
2008-10-04 | E-GEOD-11977 | biostudies-arrayexpress
TranscriptomicsHigh-resolution mapping of copy-number alterations with massively parallel sequencing
In order to benchmark the reproducibility of Affymetrix Genome-Wide Human SNP Array 6.0 for detecting copy-number alterations, we performed replicate hybridizations of 3 tumor cell lines and 2 paired normal cell lines obtained from the American Type Culture Collection (ATCC). We calculated copy numb...
ORGANISM(S): Homo sapiens 
2008-11-13 | E-GEOD-13372 | biostudies-arrayexpress
Sort   by:  
 Page size