Sort   by:  
 Page size 
TranscriptomicsValidation and copy number variation in inbred and wild mice
This SuperSeries is composed of the following subset Series: GSE24424: Copy number variation in inbred and wild mice GSE24640: Validation of a subset of copy number variants from GSE24424 by aCGH Refer to individual Series
ORGANISM(S): Mus musculus 
2010-12-31 | E-GEOD-24643 | biostudies-arrayexpress
TranscriptomicsCopy number variation in the bovine genome
Copy number variations (CNVs), which represent a significant source of genetic diversity in mammals, are currently being associated with phenotypes of clinical relevance, mostly in humans and mice. Notwithstanding, little is known about the extent of CNV that contributes to genetic variation in catt...
ORGANISM(S): Bos taurus 
2010-04-22 | E-GEOD-18174 | biostudies-arrayexpress
TranscriptomicsMouse Segmental Duplication and Copy-Number Variation
Detailed analyses of the clone-based genome assembly reveal that the recent duplication content of mouse (4.94%) is now comparable to that of human (5.5%), in contrast to previous estimates from the whole-genome shotgun sequence assembly. The architecture of mouse and human genomes differ dramatical...
ORGANISM(S): Mus musculus 
2008-05-10 | E-GEOD-11369 | biostudies-arrayexpress
TranscriptomicsCopy number variation in the genomes of twelve natural isolates of Caenorhabditis elegans
Background: Copy number variation is an important component of genetic variation in higher eukaryotes. The extent of natural copy number variation in C. elegans is unknown outside of 2 highly divergent wild isolates and the canonical N2 Bristol strain. Results: We have used array comparative genomic...
ORGANISM(S): Caenorhabditis elegans 
2010-05-17 | E-GEOD-19440 | biostudies-arrayexpress
TranscriptomicsThe impact of copy number variation on local gene expression in mouse hematopoietic stem and progenitor cells
The extent to which differences in germ line DNA copy number contribute to natural phenotypic variation is unknown. We analyzed the copy number content of the mouse genome to a sub-10 kb resolution. We identified over 1,300 copy number variant regions (CNVRs), most of which are < 10 kb in length, ar...
ORGANISM(S): Mus musculus 
2009-03-08 | E-GEOD-10656 | biostudies-arrayexpress
TranscriptomicsSomatic mosaicism for copy number variation in differentiated human tissues
Genetic variation is responsible for the generation of phenotypic diversity, including susceptibility to disease. Two major types of variation are known: single nucleotide polymorphisms (SNPs) and a more recently discovered structural variation, involving changes in copy number (CNVs) of kilobase- t...
ORGANISM(S): Homo sapiens 
2008-09-16 | E-GEOD-9598 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of mouse tissues from different mouse strains to investigate the effects of copy number variation on gene expression
Copy number variation (CNV) of DNA segments has recently been identified as a major source of genetic diversity, but a more comprehensive understanding of the extent and phenotypic effect of this type of variation is only beginning to emerge. In this study we generated genome-wide expression data fr...
ORGANISM(S): Mus musculus 
2009-02-28 | E-GEOD-10744 | biostudies-arrayexpress
TranscriptomicsMaize Inbreds Exhibit High Levels of Copy Number Variation (CNV) and Presence/Absence Variation (PAV) in Genome Content
Following the domestication of maize over the past ,10,000 years, breeders have exploited the extensive genetic diversity of this species to mold its phenotype to meet human needs. The extent of structural variation, including copy number variation (CNV) and presence/absence variation (PAV), which a...
ORGANISM(S): Zea mays 
2009-11-19 | E-GEOD-16938 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of 269 individuals from three geographically distinct human populations to investigate copy number variation
We conducted comparative genome hybridization experiments to catalogue the common copy number variation evident between 269 individuals from three geographically distinct human populations (Yoruban, Chinese/Japanese, European) against a single reference individual.
ORGANISM(S): Homo sapiens 
2006-07-31 | E-TABM-107 | biostudies-arrayexpress
TranscriptomicsCopy number variation in inbred and wild mice
Copy number variants were determined in 3-5 males from 13 inbred laboratory mouse strains and 21 Mus musculus individuals caught in various geographic locations, using Nimblegen 385k arrays. CopyMap was used to predict CNVs. 3-5 males from 13 inbred strains and 21 Mus musculus caught in various geog...
ORGANISM(S): Mus spretus 
2010-12-31 | E-GEOD-24424 | biostudies-arrayexpress
Sort   by:  
 Page size