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TranscriptomicsRadiation-specific DNA copy number aberration in rat mammary carcinoma.
Breast cancer ranks top in the incidence among the main sites of female cancer in Japan. The epidemiological study on atomic bomb survivors has suggested that the excess relative risk for breast cancer is higher than any other sites. Little is known, however, about the molecular mechanisms of breast...
ORGANISM(S): Rattus norvegicus 
2010-08-08 | E-GEOD-16128 | biostudies-arrayexpress
TranscriptomicsSingle-cell copy number varation detection
Detection of genomic rearrangements from a single cell instead of a population of cells is an emerging research technique with important applications in the study of human fertility, constitutional chromosomal disorders, and tumor progression. Here, we develop a method to improve the detection of si...
ORGANISM(S): Homo sapiens 
2011-08-23 | E-GEOD-27892 | biostudies-arrayexpress
TranscriptomicsCopy number abnormality, MYC activity and the genetic fingerprint of normal B-cells and the microRNA profile of DLBCL-77
A better understanding of the pathogenesis of diffuse large B-cell lymphoma (DLBCL) has clarified its relationship to normal B-cells, pointed to distinct mechanisms of cell transformation, and facilitated the design of novel treatments. However, these data derive from mRNA genes studies, whereas ge...
ORGANISM(S): Homo sapiens 
2010-06-22 | E-GEOD-15177 | biostudies-arrayexpress
GenomicsEvaluation of affinity-based genome-wide DNA methylation data: effects of CpG density, amplification bias and copy number variation
Abstract: DNA methylation is an essential epigenetic modification that plays a key role associated with the regulation of gene expression during differentiation but in disease states such as cancer, the DNA methylation landscape is often deregulated. There are now numerous technologies available to...
ORGANISM(S): Homo sapiens 
2010-10-08 | E-GEOD-24546 | biostudies-arrayexpress
TranscriptomicsCopy number variation analysis in the African cell line BJAB with Burkitt morphology reveals a complex 11q aberration
This study provides first molecular evidence of high-grade B-cell lymphoma with 11q aberration (HGBCL,11q) as differential diagnosis to Burkitt Lymphoma (BL) in Africa. As Zech and colleagues already noted the cell line BJAB to be an exception as BL from a 5-year Kenyan girl in being EBV-negative, l...
ORGANISM(S): Homo sapiens 
2026-01-23 | E-MTAB-16216 | biostudies-arrayexpress
TranscriptomicsCopy number variation analysis of 16HBE14o- and T84 cell lines
The aim of the project was to detect genomic regions that were normal, duplicated or deleted in these cell lines for transcription factors NFKBp50, NFkBp65, HIF1a and FAS gene which we studied. It is not clear the effects of copy number variations on allele specific assembly or disruption of mast...
ORGANISM(S): Homo sapiens 
2016-09-22 | E-MTAB-4194 | biostudies-arrayexpress
TranscriptomicsGenome-wide copy number analyses reveal genomic abnormalities involved in transformation of follicular lymphoma
We studied 277 lymphoma samples (198 FL and 79 transformed FL [tFL]) using a single-nucleotide polymorphism array to identify the secondary chromosomal abnormalities that drive the development of FL and its transformation to diffuse large B-cell lymphoma. Affymetrix 250K NspI SNP arrays were perform...
ORGANISM(S): Homo sapiens 
2015-03-30 | E-GEOD-67385 | biostudies-arrayexpress
TranscriptomicsCopy number aberrations of genes regulating normal thymus development in thymic epithelial tumors
Thymic epithelial tumors are a group of neoplasms with heterogeneous histological features and clinical behavior. The identification of markers useful to predict patient prognosis and molecular targets for therapies is limited by a very little understanding of the biology of these neoplasms. We eval...
ORGANISM(S): Homo sapiens 
2013-05-03 | E-GEOD-23540 | biostudies-arrayexpress
TranscriptomicsBreast Cancer aCGH
Genomic DNA copy number alterations are key genetic events in the development and progression of human cancers. Here we report a genome-wide microarray comparative genomic hybridization (array CGH) analysis of DNA copy number variation in a series of primary human breast tumors. We have profiled DNA...
ORGANISM(S): Homo sapiens 
2005-09-10 | E-GEOD-3281 | biostudies-arrayexpress
UnknownBreast tumor copy number aberration phenotypes and genomic instability.
Not available
S-EPMC1459181 | biostudies-literature
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